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HAPPI specifications


Unique identifier OMICS_02895
Alternative name Human Annotated and Predicted Protein Interaction
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Jake Chen

Additional information

http://discovery.informatics.uab.edu/HAPPI/help.php http://discovery.informatics.uab.edu/HAPPI/aboutUs.php

Publications for Human Annotated and Predicted Protein Interaction

HAPPI citations


Repositioning drugs by targeting network modules: a Parkinson’s disease case study

BMC Bioinformatics
PMCID: 5751600
PMID: 29297292
DOI: 10.1186/s12859-017-1889-0

[…] e genes, extracting these enriched clusters as PD-specific modules. 5) We constructed PD-specific network module by retrieving the gene-gene interactions for the genes in PD-specific modules from the HAPPI-2 database []. 6) Finally, we annotated PD-specific modules with functional groups using ClueGO [].Fig. 1 The Drug repositioning section (green) was comprised of four steps. First, we calculated […]


Systems Biology Approach to Identify Gene Network Signatures for Colorectal Cancer

Front Genet
PMCID: 3354560
PMID: 22629282
DOI: 10.3389/fgene.2012.00080

[…] In this work, we integrated prior knowledge from gene signatures (curated gene sets from MSigDB and GeneSigDB databases) and protein interactions (high-quality interaction data from HAPPI) with GSEA, and gene/protein network modeling together to identify gene network signatures from gene expression microarray data. We demonstrated how to apply this approach into discovering gene […]


Labeling Emotions in Suicide Notes: Cost Sensitive Learning with Heterogeneous Features

PMCID: 3409483
PMID: 22879765
DOI: 10.4137/BII.S8930

[…] es. These include: – The stem form of words, obtained using the implementation of the Porter Stemmer in the Natural Language Toolkit (eg, happy, happiness, happily, etc. all activate the stem feature happi).– Bigrams of stems, created from pairs of stems appearing in sequence (eg, happy days activates the bigram feature happi day).– Lexicalized part-of-speech, formed of word stems concatenated wit […]


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HAPPI institution(s)
Wenzhou Medical University First Affiliate Hospital, Wenzhou, China; Medeolinx, LLC, Indianapolis, IN, USA; The Informatics Institute, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; Indiana Center for Systems Biology and Personalized Medicine, Indiana University School of Informatics and Computing, Indianapolis, IN, USA
HAPPI funding source(s)
Supported by a National Institute of Health grant (2U01DK084536-06); by Indiana Center for Systems Biology and Personalized Medicine, and by the Wenzhou Medical University First Affiliate Hospital at Wenzhou, Zhejiang China.

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