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HELIQUEST specifications


Unique identifier OMICS_17721
Interface Web user interface
Restrictions to use None
Output data Text files or PDF
Programming languages Python
Computer skills Basic
Stability Stable
Maintained Yes

Publication for HELIQUEST

HELIQUEST citations


A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

Nat Commun
PMCID: 5889406
PMID: 29626194
DOI: 10.1038/s41467-018-03717-8

[…] give the first and last amino acid in the protein sequence, with the total length of each protein given in bracketsb length is based on structural data, when available, and visual inspection using heliquest. prolines are considered as helix breakersc hydrophobic moment is calculated using heliquest. the ahs that contain 11-mer repeats are plotted as 3–11 helices. for longer ahs (*), the mean […]


Discovery of Distinctin Like Peptide PH (DLP PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide

Front Microbiol
PMCID: 5876494
PMID: 29628917
DOI: 10.3389/fmicb.2018.00541

[…] models were quantified by ramachandran plots using rampage (lovell et al., ) and by z-scores using prosa (wiederstein and sippl, ). the physiochemical parameters of the amps were predicted using heliquest (gautier et al., )., as dlp-ph was more effective against the growth of e. coli, we aimed to simulate the antimicrobial mechanism using the e. coli membrane model (pandit and klauda, ), […]


Membrane association of EMR2/ADGRE2 NTF is regulated by site specific N glycosylation

Sci Rep
PMCID: 5852045
PMID: 29540735
DOI: 10.1038/s41598-018-22849-x

[…] the template., protein secondary structure and amphipathic α-helix prediction was done using amphipaseek v1.3.5 program as described,. helical-wheel projections of peptides were predicted using the heliquest server as described. cell lysates were collected by cell lysis in modified ripa lysis buffer (20 mm trishcl ph 7.4, 5 mm mgcl2, 100 mm nacl, 0.5% np-40 and 1x complete protease inhibitors) […]


A sophisticated, differentiated Golgi in the ancestor of eukaryotes

BMC Biol
PMCID: 5840792
PMID: 29510703
DOI: 10.1186/s12915-018-0492-9

[…] were likely present in the leca., mammalian gmap210 contains an n-terminal amphipathic alpha helix (alps domain), which is important for tethering er-derived vesicles to the cis-golgi []. using the heliquest web service [], we did not identify any such helices in the first 80 residues of gmap210 sequences from non-vertebrates, suggesting that this is a lineage-specific mechanism for recognition […]


Peroxiredoxins and Redox Signaling in Plants

PMCID: 5806080
PMID: 28594234
DOI: 10.1089/ars.2017.7164

[…] as proposed for the human prdx2 membrane interaction model (). protons or ca2+ ions may neutralize the negatively charged hydrophobic faces to imbed 2-cysprx in the membrane., the analysis with the heliquest program used the default settings. regions of at2-cysprx were selected with minimum 50% α-helical character, but no β-strand content and no dimer–dimer interaction site (). secondary […]


Structural properties of apolipoprotein A I mimetic peptides that promote ABCA1 dependent cholesterol efflux

Sci Rep
PMCID: 5811490
PMID: 29440748
DOI: 10.1038/s41598-018-20965-2

[…] hydrophobic moment is calculated as the vectorial sum of all the hydrophobicity indices, divided by the number of residues. helical wheel representations of the peptides helixes were generated by heliquest server freely available online., peptide height was calculated from the time series of the vertical distance between centers of geometry of backbones of peptides and c2 atoms of oleoyl acyl […]

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HELIQUEST institution(s)
Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis and CNRS, Valbonne, France
HELIQUEST funding source(s)
This work was supported by the Agence Nationale pour la Recherche and the CNRS (RISC).


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