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- person_outline Herrmann-Georg Holzhutter
Publication for HepatoNet1
Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
[…] e example parameters within physiological ranges and do not attempt to model the particular compound. The model is meant to be an example of the simulation approach. The PBPK model was connected with HepatoNet1 GSMN. The nuclear receptor model controlling CYP3A4 was incorporated from a previously published study. Overall, we demonstrate how to connect three different models into one multiscale sys […]
Metabolic Consequences of TGFβ Stimulation in Cultured Primary Mouse Hepatocytes Screened from Transcript Data with ModeScore
[…] Metabolism is represented by a modified version of HepatoNet1  (see and ) and 987 reference functions (see and ) for which flux distributions have been computed using FASIMU , see . In the ModeScore method (, see also ) a regulation amplitude […]
Integrating Cellular Metabolism into a Multiscale Whole Body Model
[…] ls (Figure S1 in ). The approach allows the representation of human metabolism under simultaneous consideration of quantitative availability of substances at the organism level (). We exemplarily use HepatoNet1 , a genome-scale model of human hepatic metabolism to analyze specific responses of the network in the face of time-dependent concentration profiles in liver tissue. Following this approach […]
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