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HepatoNet1 specifications


Unique identifier OMICS_20374
Name HepatoNet1
Restrictions to use Academic or non-commercial use
Community driven No
Data access File download
User data submission Not allowed
Content license Creative Commons Attribution-Noncommercial-Share Alike 3.0
Maintained Yes


  • person_outline Herrmann-Georg Holzhutter

Publication for HepatoNet1

HepatoNet1 citations


Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics

PMCID: 5702902
PMID: 28782239
DOI: 10.1002/psp4.12230

[…] e example parameters within physiological ranges and do not attempt to model the particular compound. The model is meant to be an example of the simulation approach. The PBPK model was connected with HepatoNet1 GSMN. The nuclear receptor model controlling CYP3A4 was incorporated from a previously published study. Overall, we demonstrate how to connect three different models into one multiscale sys […]


Metabolic Consequences of TGFβ Stimulation in Cultured Primary Mouse Hepatocytes Screened from Transcript Data with ModeScore

PMCID: 3901234
PMID: 24957771
DOI: 10.3390/metabo2040983

[…] Metabolism is represented by a modified version of HepatoNet1 [] (see and ) and 987 reference functions (see and ) for which flux distributions have been computed using FASIMU [], see . In the ModeScore method ([], see also ) a regulation amplitude […]


Integrating Cellular Metabolism into a Multiscale Whole Body Model

PLoS Comput Biol
PMCID: 3486908
PMID: 23133351
DOI: 10.1371/journal.pcbi.1002750

[…] ls (Figure S1 in ). The approach allows the representation of human metabolism under simultaneous consideration of quantitative availability of substances at the organism level (). We exemplarily use HepatoNet1 , a genome-scale model of human hepatic metabolism to analyze specific responses of the network in the face of time-dependent concentration profiles in liver tissue. Following this approach […]


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HepatoNet1 institution(s)
Institute of Biochemistry, University Medicine Charite Berlin, Berlin, Germany; Institute of Zoology, Bioquant BQ 0018, University Heidelberg, Heidelberg, Germany; International Institute of Molecular and Cell Biology, Warsaw, Poland; Department of Bioinformatics, Friedrich-Schiller-University Jena, Jena, Germany
HepatoNet1 funding source(s)
Supported by the German Systems Biology Program ‘HepatoSys’, grant no. 0313078.

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