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|Alternative name||Heterogeneity in DNA Methylation|
|Restrictions to use||None|
|Data access||File download, Browse|
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- person_outline Wenfeng Qian
Publication for Heterogeneity in DNA Methylation
Epigenetic regulation of gene expression in cancer: techniques, resources and analysis
[…] mine differentially that distinguish sample phenotypes . Variably methylated regions inferred with bump-hunting  and outlier-based analysis algorithms  are ideally suited to capture inter-tumor heterogeneity in DNA methylation alterations.Because MBD-seq data obtain calls of methylated regions, alternative statistical methods either comparing the signal relative to input control or comparing […]
Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae
[…] enome copies (MMP = 0.92). In this context, this finding suggests that the Spn556II recognition sequence is methylated in some of pneumococcal cells.To uncover the molecular and genetic basis of this heterogeneity in DNA methylation, we characterized the Spn556II locus in this study. The Spn556II locus in ST556 consists of 8,076 nucleotides or six genes (). The first two genes code for two of the […]
Functional annotation of the human brain methylome identifies tissue specific epigenetic variation across brain and blood
[…] are significantly hypomethylated compared to CGI shores and the gene body, with no overall difference in canonical methylation patterns between tissues or individuals. There is, however, considerable heterogeneity in DNA methylation across different categories of CGI, dependent upon genomic location, with promoter CGIs being significantly hypomethylated in comparison to intragenic, 3' UTR, and int […]
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