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HeteroMeth specifications


Unique identifier OMICS_32184
Name HeteroMeth
Alternative name Heterogeneity in DNA Methylation
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline Wenfeng Qian

Publication for Heterogeneity in DNA Methylation

HeteroMeth citations


Epigenetic regulation of gene expression in cancer: techniques, resources and analysis

Brief Funct Genomics
PMCID: 5860551
PMID: 28968850
DOI: 10.1093/bfgp/elx018

[…] mine differentially that distinguish sample phenotypes []. Variably methylated regions inferred with bump-hunting [] and outlier-based analysis algorithms [] are ideally suited to capture inter-tumor heterogeneity in DNA methylation alterations.Because MBD-seq data obtain calls of methylated regions, alternative statistical methods either comparing the signal relative to input control or comparing […]


Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae

PLoS Pathog
PMCID: 4948785
PMID: 27427949
DOI: 10.1371/journal.ppat.1005762

[…] enome copies (MMP = 0.92). In this context, this finding suggests that the Spn556II recognition sequence is methylated in some of pneumococcal cells.To uncover the molecular and genetic basis of this heterogeneity in DNA methylation, we characterized the Spn556II locus in this study. The Spn556II locus in ST556 consists of 8,076 nucleotides or six genes (). The first two genes code for two of the […]


Functional annotation of the human brain methylome identifies tissue specific epigenetic variation across brain and blood

Genome Biol
PMCID: 3446315
PMID: 22703893
DOI: 10.1186/gb-2012-13-6-r43

[…] are significantly hypomethylated compared to CGI shores and the gene body, with no overall difference in canonical methylation patterns between tissues or individuals. There is, however, considerable heterogeneity in DNA methylation across different categories of CGI, dependent upon genomic location, with promoter CGIs being significantly hypomethylated in comparison to intragenic, 3' UTR, and int […]


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HeteroMeth institution(s)
State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China
HeteroMeth funding source(s)
Supported by the Strategic Priority Research Program of Chinese Academy of Sciences, China awarded (Grant No. XDA08020303).

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