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Hexicon specifications


Unique identifier OMICS_06885
Name Hexicon
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Version 2.0
Stability Stable
Maintained Yes




No version available


  • person_outline Andreas Winkler

Additional information


Publications for Hexicon

Hexicon citations


Long range allosteric signaling in red light–regulated diguanylyl cyclases

Sci Adv
PMCID: 5336353
PMID: 28275738
DOI: 10.1126/sciadv.1602498

[…] Peptides were then infused into a maXis electrospray ionization ultrahigh-resolution time-of-flight (UHR-TOF) mass spectrometer (Bruker). Deuterium incorporation was analyzed and quantified using the Hexicon 2 software package (http://hx2.mpimf-heidelberg.mpg.de) (). […]


A Roving Dual Presentation Simultaneity Judgment Task to Estimate the Point of Subjective Simultaneity

Front Psychol
PMCID: 4805589
PMID: 27047434
DOI: 10.3389/fpsyg.2016.00416

[…] + SOAt)2/σ2, its denominator's non-centrality parameter is (μ + SOAn)2/σ2, and both numerator and denominator have one degree of freedom (Morgan et al., ). In our Matlab code (available at http://www.hexicon.co.uk/Kielan/) we made use of a saddle-point approximation to the doubly non-central F cumulative distribution function (Butler and Paolella, ; Paolella, ).So far, the model simulates an unbia […]


Blue light induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence

PMCID: 4721966
PMID: 26754770
DOI: 10.7554/eLife.11860.031

[…] ). Eluting peptides were infused into a maXis electrospray ionization-ultra high resolution-time-of-flight mass spectrometer (Bruker) and deuterium incorporation was analyzed and quantified using the Hexicon 2 software package (). […]


Applications of hydrogen deuterium exchange (HDX) for the characterization of conformational dynamics in light activated photoreceptors

Front Mol Biosci
PMCID: 4477167
PMID: 26157802
DOI: 10.3389/fmolb.2015.00033

[…] zation for interactive parameterization. HDX-Workbench [] is geared toward high-resolution HDX-MS data and offers a comprehensive graphical interface with visualization and manipulation capabilities. Hexicon 2 [] adapted and extended the regularized feature detection and deuteration distribution estimation algorithms from its predecessor [] for improved performance with high-resolution data. This […]


QUDeX MS: hydrogen/deuterium exchange calculation for mass spectra with resolved isotopic fine structure

BMC Bioinformatics
PMCID: 4274694
PMID: 25495703
DOI: 10.1186/s12859-014-0403-1

[…] mber of computational utilities have been introduced to streamline the analysis of HDX MS data, including HDX-Analyzer [], HX-Express [], Deuterator [], HD Desktop [], DEX [], Hydra [], TOF2H [], and Hexicon [,].One caveat of HDX MS data analysis is that at typical resolving powers (including relatively high resolving powers routinely obtained on FT-Orbitrap instruments), peptide deuteration is de […]


Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States☆

J Mol Biol
PMCID: 3989770
PMID: 24291457
DOI: 10.1016/j.jmb.2013.11.018
call_split See protocol

[…] esolution–time-of-flight mass spectrometer (Bruker) for measuring the extent of deuterium incorporation. We analyzed deuterium incorporation with an improved version of the automated software package Hexicon . This in-house version (manuscript in preparation) is based on the previously published NITPICK algorithm for feature detection and Hexicon for the analysis of deuterium incorporation. Deute […]


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Hexicon institution(s)
Interdisciplinary Center for Scientific Computing, University of Heidelberg, Heidelberg, Germany; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH-Allianz, Heidelberg, Germany; Proteomics Center at Children’s Hospital Boston, Boston, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA
Hexicon funding source(s)
Supported by the Deutsche Forschungsgemeinschaft (SFB638, HA-4364/2) and the Alexander von Humboldt Foundation (3.1-DEU/1134241), the Heinz Goetze Memorial Fellowship, the Helmholtz Alliance on Systems Biology and Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences.

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