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chevron_left Hydrogen-deuterium exchange chevron_right
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Hexicon specifications

Information


Unique identifier OMICS_06885
Name Hexicon
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Version 2.0
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Andreas Winkler <>

Additional information


https://hci.iwr.uni-heidelberg.de/hci/softwares/hexicon

Publications for Hexicon

Hexicon in publications

 (7)
PMCID: 5336353
PMID: 28275738
DOI: 10.1126/sciadv.1602498

[…] were then infused into a maxis electrospray ionization ultrahigh-resolution time-of-flight (uhr-tof) mass spectrometer (bruker). deuterium incorporation was analyzed and quantified using the hexicon 2 software package (http://hx2.mpimf-heidelberg.mpg.de) ()., trypsin digestion patterns of all three padc homologs were obtained by following the proteolytic degradation over 60 min […]

PMCID: 4805589
PMID: 27047434
DOI: 10.3389/fpsyg.2016.00416

[…] soat)2/σ2, its denominator's non-centrality parameter is (μ + soan)2/σ2, and both numerator and denominator have one degree of freedom (morgan et al., ). in our matlab code (available at http://www.hexicon.co.uk/kielan/) we made use of a saddle-point approximation to the doubly non-central f cumulative distribution function (butler and paolella, ; paolella, )., so far, the model simulates […]

PMCID: 4721966
PMID: 26754770
DOI: 10.7554/eLife.11860.031

[…] eluting peptides were infused into a maxis electrospray ionization-ultra high resolution-time-of-flight mass spectrometer (bruker) and deuterium incorporation was analyzed and quantified using the hexicon 2 software package ()., saxs measurements were performed at the x12sa csaxs beamline at the swiss light source (villigen, switzerland). measurements were performed in buffer c at protein […]

PMCID: 4477167
PMID: 26157802
DOI: 10.3389/fmolb.2015.00033

[…] for interactive parameterization. hdx-workbench [] is geared toward high-resolution hdx-ms data and offers a comprehensive graphical interface with visualization and manipulation capabilities. hexicon 2 [] adapted and extended the regularized feature detection and deuteration distribution estimation algorithms from its predecessor [] for improved performance with high-resolution data. […]

PMCID: 3989770
PMID: 24291457
DOI: 10.1016/j.jmb.2013.11.018

[…] mass spectrometer (bruker) for measuring the extent of deuterium incorporation. we analyzed deuterium incorporation with an improved version of the automated software package hexicon . this in-house version (manuscript in preparation) is based on the previously published nitpick algorithm for feature detection and hexicon for the analysis of deuterium incorporation. […]


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Hexicon institution(s)
Interdisciplinary Center for Scientific Computing, University of Heidelberg, Heidelberg, Germany; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH-Allianz, Heidelberg, Germany; Proteomics Center at Children’s Hospital Boston, Boston, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA
Hexicon funding source(s)
Supported by the Deutsche Forschungsgemeinschaft (SFB638, HA-4364/2) and the Alexander von Humboldt Foundation (3.1-DEU/1134241), the Heinz Goetze Memorial Fellowship, the Helmholtz Alliance on Systems Biology and Heidelberg Graduate School of Mathematical and Computational Methods for the Sciences.

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