A relatively comprehensive database for human histone modifications. HHMD focuses on the storage and integration of histone modification datasets that were obtained from laboratory experiments. HHMD contains four types of data: (i) high-throughput histone modifications, (ii) MeDIP methylation, (iii) curated information of aberrant histone modifications, genes and cancers and (iv) GC contents, RefSeq gene (21) and other genomic annotations. To facilitate data extraction, flexible search options are built in HHMD. It can be searched by histone modification, gene ID, functional categories, chromosome location and cancer name. HHMD also includes a user-friendly visualization tool named HisModView, by which genome-wide histone modification map can be shown. HisModView facilitates the acquisition and visualization of histone modifications. The database also has manually curated information of histone modification dysregulation in nine human cancers.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
HHMD funding source(s)
National Natural Science Foundation of China (Grant No. 30871394); the National High Tech Development Project of China, the 863 Program (Grant No. 2007AA02Z329); the National Basic Research Program of China, the 973 Program (Grant No. 2008CB517302); the Natural Science Foundation of Heilongjiang Province (Grant No. D2007-35); the Innovation and Technology special Fund for researchers of Harbin (Grant No. RC2007LX003004)