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RNAi is a process in which gene expression is inhibited by small RNA molecules such as small interfering RNAs (siRNAs) and short hairpin RNAs. High-throughput RNAi screening is a breakthrough technology for functional genomics and for drug target discovery (Orvedahl et al., 2011; Whitehurst et al., 2007). A frequently used screening platform uses 96-well or 384-well microtiter plates, on which each well contains siRNA oligos designed to target a specific gene. Source text: Zhong et al., 2013.