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HIVcleave specifications


Unique identifier OMICS_18476
Name HIVcleave
Interface Web user interface
Restrictions to use None
Input data A protein sequence.
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Shen H.B.

Publication for HIVcleave

HIVcleave citations


HIV 1 IN/Pol recruits LEDGF/p75 into viral particles

PMCID: 4357141
PMID: 25809198
DOI: 10.1186/s12977-014-0134-4

[…] of rtv is required to completely block pr (additional file : figure s4c). as an internal control we used the globular protein bsa, which is not cleaved by pr (figure a,c).figure 2, using hivcleave, a hiv pr cleavage prediction program [], we found several predicted cleavable octapeptides in ledgf/p75 (data not shown). we then subjected highly purified recombinant ledgf/p75 to hiv-1 […]


Find novel dual agonist drugs for treating type 2 diabetes by means of cheminformatics

Drug Des Devel Ther
PMCID: 3623550
PMID: 23630413
DOI: 10.2147/DDDT.S42113

[…] for predicting subcellular localization of eukaryotic and human proteins,, nr-2l for identifying nuclear receptors and their subfamilies, protident for identifying proteases and their types, and hivcleave for predicting human immunodeficiency virus protease cleavage sites in proteins,, can provide timely and very useful information, as well as insights for drug development. in addition […]


Design Novel Dual Agonists for Treating Type 2 Diabetes by Targeting Peroxisome Proliferator Activated Receptors with Core Hopping Approach

PLoS One
PMCID: 3369836
PMID: 22685582
DOI: 10.1371/journal.pone.0038546

[…] enzyme class, iloc-euk and iloc-hum for predicting subcellular localization of eukaryotic and human proteins, nr-2l and inr-physchem for identifying nuclear receptors and their subfamilies, and hivcleave for predicting hiv protease cleavage sites in proteins , , can timely provide very useful information and insights for drug development. the software of “core hopping” is another […]


Predicting Bevirimat resistance of HIV 1 from genotype

BMC Bioinformatics
PMCID: 3224585
PMID: 20089140
DOI: 10.1186/1471-2105-11-37

[…] index from 0 (unreliable) through 9 (highly reliable) for each residue being in a predicted secondary structure state., hiv protease cleavage sites for all p2 sequences were predicted with hivcleave [] based on earlier work by chou et al. []., all models were compared by applying wilcoxon signed-rank test [] on the auc distributions from the 100-fold leave-one-out cross-validation runs […]


How to find simple and accurate rules for viral protease cleavage specificities

BMC Bioinformatics
PMCID: 2698905
PMID: 19445713
DOI: 10.1186/1471-2105-10-149

[…] operator characteristic (roc) curve. the roc plots for the osre hiv-1 rules are shown in figure and figure , together with the same values for the rough set theory rules [], the recently published hivcleave web-server [], and a linear support vector machine [], which was the best predictor we had hitherto tried for this problem. the positive likelihood ratio is shown in table , together […]

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HIVcleave institution(s)
Gordon Life Science Institute, San Diego, CA, USA; Institute of Image Processing & Pattern Recognition, Shanghai Jiaotong University, Shanghai, China

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