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HMDD specifications


Unique identifier OMICS_02799
Alternative name Human MicroRNA and Disease Database
Restrictions to use Academic or non-commercial use
Database management system SQLite
Community driven No
Data access File download, Browse
User data submission Allowed
Version 3.0
Maintained No


  • Primates
    • Homo sapiens


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Publications for Human MicroRNA and Disease Database

HMDD citations


Prediction of microRNA disease associations based on distance correlation set

BMC Bioinformatics
PMCID: 5905221
PMID: 29665774
DOI: 10.1186/s12859-018-2146-x

[…] loping efficient, successful computational approaches that predict potential miRNA-disease associations is challenging and urgently needed.Recently, several heterogeneous biological datasets, such as HMDD and miR2Disease, have been constructed [–], and several computational methods are used to predict potential miRNA-disease associations based these datasets [–]. For example, Jiang et al. develope […]


SRMDAP: SimRank and Density Based Clustering Recommender Model for miRNA Disease Association Prediction

Biomed Res Int
PMCID: 5884242
PMID: 29750163
DOI: 10.1155/2018/5747489
call_split See protocol

[…] tabase [] (, DisGeNET 4.0: October 2016) to construct a disease similarity network. Experimentally verified miRNA-disease network was downloaded from the HMDD v2.0 database [] (, Jun-14-2014 Version). […]


Bioinformatic analysis and prediction of the function and regulatory network of long non coding RNAs in hepatocellular carcinoma

PMCID: 5934726
PMID: 29740493
DOI: 10.3892/ol.2018.8271

[…] eract with HULC, so further analyses were performed on HOTAIR and MALAT1 only. A total of 11 overlaps were identified between HOTAIR and MALAT1, 9 of which were HCC-associated miRNAs according to the HMDD database. hsa-miR-1 and hsa-miR20a-5p were identified to be downregulated in HCC and selected for further analysis.ChIPBase was used to predict the transcription factors for lncRNAs (MALAT1 and H […]


A Semi Supervised Learning Algorithm for Predicting Four Types MiRNA Disease Associations by Mutual Information in a Heterogeneous Network

PMCID: 5867860
PMID: 29498680
DOI: 10.3390/genes9030139

[…] study of miRNAs, and numerous miRNAs have been identified. Furthermore, a great deal of databases have been established to provide information on miRNAs, such as the Human microRNA Disease Database (HMDD) [], miR2Disease [], database of Differentially Expressed miRNAs in human Cancers (dbDEMC) [] and so on. It has been demonstrated that dysregulation of miRNAs may lead to a variety of diseases [, […]


Finite size effects in transcript sequencing count distribution: its power law correction necessarily precedes downstream normalization and comparative analysis

Biol Direct
PMCID: 5809866
PMID: 29433547
DOI: 10.1186/s13062-018-0204-y

[…] om Table before and after power-law correction were independently subjected to gene-set enrichment analysis (GSEA) via the MiEAA webserver to identify plausible disease groups from the collection of Human microRNA and Disease Database (HMDD). Briefly, using the Bowtie1-mapped results from Table , the concordance transcripts across the 4 comparisons before power-law correction (see “intersect row” […]


Molecular Network Based Identification of Competing Endogenous RNAs in Thyroid Carcinoma

PMCID: 5793195
PMID: 29351231
DOI: 10.3390/genes9010044

[…] and RNA competing mechanisms. Fortunately, there are many well-established RNA databases such as long-non-coding RNA-associated diseases (LncRNADisease) database [], the Human miRNA Disease Database (HMDD) [], and database of Differentially Expressed MiRNAs in human Cancers dbDEMC []. In addition, miRNA-target interaction databases including miRcode [] and miRanda [,,,,,,,], and ceRNA databases su […]


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HMDD institution(s)
1Department of Biomedical Informatics, Department of Physiology and Pathophysiology, Center for Noncoding RNA Medicine, MOE Key Lab of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing, China; Institute of Computational Medicine, School of Artificial Intelligence, Hebei University of Technology, Tianjin, China; Center of Bioinformatics, Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
HMDD funding source(s)
Supported by Special Project on Precision Medicine under the National Key R&D Program [2016YFC0903000]; National Natural Science Foundation of China [81670462, 81672113, 31801099]; Fundamental Research Funds for Central Universities of China [BMU2017YJ004].

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