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HOmo sapiens COmprehensive MOdel COllection HOCOMOCO

Online

Contains transcription factor (TF) binding models obtained by careful integration of data from different sources. HOCOMOCO v10 contains non-redundant curated binding models for 601 human and 396 mouse TFs. The update is based on the analysis of massive ChIP-Seq and HT-SELEX datasets, with the validation of the resulting models on in vivo data. To facilitate a practical application, all HOCOMOCO models are linked to gene and protein databases (Entrez Gene, HGNC, UniProt) and accompanied by precomputed score thresholds. We provide command-line tools for position weight matrix (PWM) and diPWM threshold estimation and motif finding in nucleotide sequences. The HOCOMOCO website was fully redesigned to provide a system of interactive filters making it easier to browse the tables of the collection.

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HOCOMOCO classification

  • Animals
    • Homo sapiens
    • Mus musculus

HOCOMOCO specifications

Restrictions to use:
None
Maintained:
Yes
Version:
10.0

HOCOMOCO support

Maintainer

  • Ivan Kulakovskiy <>

Credits

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Publications

Institution(s)

Laboratory of Bioinformatics and Systems Biology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Department of Computational Systems Biology, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center, Thuwal, Jeddah, Saudi Arabia; Yandex Data Analysis School, Data Analysis Department, Moscow Institute of Physics and Technology, Leo, Moscow, Russia; Department of Molecular and Biological Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow, Russia

Funding source(s)

Russian Foundation for Basic Research [15-34-20423]; Russian Foundation for Basic Research [14-04-01838]; Russian Science Foundation [14-50-00060]; Dynasty Foundation Fellowship; Russian Science Foundation [15-14-30002]; KAUST base research fund

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