Contains transcription factor (TF) binding models obtained by careful integration of data from different sources. HOCOMOCO v10 contains non-redundant curated binding models for 601 human and 396 mouse TFs. The update is based on the analysis of massive ChIP-Seq and HT-SELEX datasets, with the validation of the resulting models on in vivo data. To facilitate a practical application, all HOCOMOCO models are linked to gene and protein databases (Entrez Gene, HGNC, UniProt) and accompanied by precomputed score thresholds. We provide command-line tools for position weight matrix (PWM) and diPWM threshold estimation and motif finding in nucleotide sequences. The HOCOMOCO website was fully redesigned to provide a system of interactive filters making it easier to browse the tables of the collection.