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HomoloGene specifications


Unique identifier OMICS_01544
Name HomoloGene
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline Eric W Sayers

Publication for HomoloGene

HomoloGene citations


A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals

BMC Genomics
PMCID: 5896114
PMID: 29642853
DOI: 10.1186/s12864-018-4647-4

[…] es-specific genes that may play a key role in metabolic variance among different organisms and to further scrutinize the five species genome-specific genes identified by Ensembl Compara, we also used HomoloGene (https://www.ncbi.nlm.nih.gov/homologene) [], TreeFam (Release 9, March 2013, 109 species, 15,736 families) (http://www.treefam.org/) and OrthoDB v9 (http://www.orthodb.org/) and assessed o […]


A high throughput, functional screen of human Body Mass Index GWAS loci using tissue specific RNAi Drosophila melanogaster crosses

PLoS Genet
PMCID: 5897035
PMID: 29608557
DOI: 10.1371/journal.pgen.1007222

[…] s according to DIOPT—DRSC Integrative Ortholog Prediction Tool (http://www.flyrnai.org/diopt)[], as well as pairwise alignments generated using BLAST of NCBI (for example: http://www.ncbi.nlm.nih.gov/homologene/?term=ADCY9). In Step 4, we obtained available RNAi knockdown lines for each of the fly orthologs from Step 3, and crossed these with flies containing tissue-specific drivers to knock down […]


Long lived rodents reveal signatures of positive selection in genes associated with lifespan

PLoS Genet
PMCID: 5884551
PMID: 29570707
DOI: 10.1371/journal.pgen.1007272

[…] PosiGene pipeline []. Giant mole-rat was used as PosiGene’s anchor species. Orthology was determined by PosiGene via best bidirectional BLAST searches [, ] against the orthologs groups defined in the HomoloGene [] database (PosiGene parameter -hs for HomoloGene species and -nhs for species not included in the database). Regarding the silvery mole-rat, for which we had both a genome and a transcrip […]


Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor

Sci Rep
PMCID: 5838214
PMID: 29507327
DOI: 10.1038/s41598-018-22405-7

[…] Protein sequence alignment showed that Tshr is revolutionarily conserved in rat and human (HomoloGene in NCBI). To verify the predicted transcripts in NCBI website, we extracted the total RNA from thyroid glands of 3 wild-type (WT) SD rats and designed specific PCR primers to distinguish th […]


Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal dominant non syndromic hearing loss

J Med Genet
PMCID: 5931241
PMID: 29453195
DOI: 10.1136/jmedgenet-2017-104954

[…] y modelling program (http://swissmodel.expasy.org/workspace/). Data obtained by the homology models were visualised using Swiss-PdbViewer 4.1. Multiple sequence alignment was performed according to a Homologene program. […]


Age Associated Decline in Thymic B Cell Expression of Aire and Aire Dependent Self Antigens

Cell Rep
PMCID: 5813500
PMID: 29386114
DOI: 10.1016/j.celrep.2018.01.015
call_split See protocol

[…] linkage as agglomeration method), and volcano plot were generated using R/Bioconductor (https://www.bioconductor.org). The mouse Aire-dependent B cell-specific list was mapped to human homologs using Homologene identifiers downloaded from MGI (http://www.informatics.jax.org). Genes from any list that did not map to gene symbols in our dataset were omitted from further analysis. […]


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HomoloGene institution(s)
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA

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