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Can we predict protein-protein interactions (PPIs) of a novel virus with its host? Three major problems arise: the lack of known PPIs for that virus to learn from, the cost of learning about its proteins and the sequence dissimilarity among viral families that makes most methods inapplicable or inefficient.
(Eid et al., 2016) DeNovo: virus-host sequence-based protein-protein interaction prediction. Bioinformatics.