HotMAPS specifications


Unique identifier OMICS_28735
Name HotMAPS
Alternative name Hotspot Missense mutation Areas in Protein Structures
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
License Apache License version 2.0
Computer skills Advanced
Version 1.1.3
Stability Stable
Maintained Yes




No version available


  • person_outline Rachel Karchin
  • person_outline Collin Tokheim

Publication for Hotspot Missense mutation Areas in Protein Structures

HotMAPS citation


3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

Genome Med
PMCID: 5260099
PMID: 28115009
DOI: 10.1186/s13073-016-0393-x

[…] ssay and gene expression profile of numerous low frequency somatic genetic variants by Kim et al. [] supports this observation: All mutations identified by Mutation3D and most mutations identified by HotMAPS that were shown to be functional in the screen were single-residue hotspots, whereas our method and Hotspot3D were able to identify significantly more of the functional rare mutations. Finally […]

HotMAPS institution(s)
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA; In Silico Solutions, Fairfax, VA, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
HotMAPS funding source(s)
Supported by National Institutes of Health, National Cancer Institute fellowship F31CA200266 and grant U01CA180956.

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