HotMAPS specifications

Information


Unique identifier OMICS_28735
Name HotMAPS
Alternative name Hotspot Missense mutation Areas in Protein Structures
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
License Apache License version 2.0
Computer skills Advanced
Version 1.1.3
Stability Stable
Maintained Yes

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Versioning


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Maintainers


  • person_outline Rachel Karchin
  • person_outline Collin Tokheim

Publication for Hotspot Missense mutation Areas in Protein Structures

HotMAPS citation

library_books

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

2017
Genome Med
PMCID: 5260099
PMID: 28115009
DOI: 10.1186/s13073-016-0393-x

[…] ssay and gene expression profile of numerous low frequency somatic genetic variants by Kim et al. [] supports this observation: All mutations identified by Mutation3D and most mutations identified by HotMAPS that were shown to be functional in the screen were single-residue hotspots, whereas our method and Hotspot3D were able to identify significantly more of the functional rare mutations. Finally […]

HotMAPS institution(s)
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA; In Silico Solutions, Fairfax, VA, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
HotMAPS funding source(s)
Supported by National Institutes of Health, National Cancer Institute fellowship F31CA200266 and grant U01CA180956.

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