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HotPoint specifications


Unique identifier OMICS_05406
Name HotPoint
Interface Web user interface
Restrictions to use None
Input data A protein complex and two chain identifiers that form an interface.
Input format PDB
Output data The hot spot prediction results, a table of residue properties and an interactive 3D visualization of the complex with hot spots highlighted.
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Attila Gursoy <>
  • person_outline Ozlem Keskin <>

Additional information

Publications for HotPoint

HotPoint in publications

PMCID: 5558186
PMID: 28815022
DOI: 10.1186/s13628-017-0037-6

[…] coth []. predictions by these tools were obtained from their respective web servers by entering pdb ids, and the top scoring predicted complex was selected., we used the consensus set of kfc2 [] and hotpoint [] server predictions to extract the specific amino acid positions of the interface region from prism predicted complexes. the structures of the domains containing interface regions […]

PMCID: 5450538
PMID: 28475149
DOI: 10.3390/md15050132

[…] products with structural diversity and pharmacological perspective. in the past 10 years, the discovery of bioactive marine natural products from marine cyanobacteria has become a new research hotpoint in the field of marine natural products since a large number of bioactive cyclic peptides have been derived from marine cyanobacteria. the structural characteristics of cyclic peptides […]

PMCID: 5323130
PMID: 27533458
DOI: 10.18632/oncotarget.11274

[…] supporting information (). anchor residues can be either identified by experimental approach like alanine-scanning mutagenesis [] or computational prediction methods (robetta [], kfc2 [], predhs [], hotpoint [], mm/pb(gb)sa [], foldx [] and so on). in this study, the crystal structure of hpd-1/hpd-l1 complex (pdb code: 4zqk) [] was used as the input structure and three in silico hotspot […]

PMCID: 4871372
PMID: 27187593
DOI: 10.1371/journal.pone.0152805

[…] for full coverage, the participant wore a long-sleeved shirt and long trousers. for partial coverage, sleeves were rolled up to above the elbow and shorts were worn., an automatic washing machine (hotpoint, model wmsl 521p, peterborough, uk) was used to wash the clothes. separate washing machines were used for the control and treated clothing. the machines were set for an eco-cycle […]

PMCID: 4684219
PMID: 26675422
DOI: 10.1371/journal.pone.0144486

[…] assessed its performance via cross-validation and independent dataset test. the results show that our method achieves higher prediction performance than well-known methods such as robetta, foldx and hotpoint. we conclude that these contact descriptors, in particular the novel co-occurring atomic contacts, can be used to facilitate accurate and interpretable characterization of protein binding […]

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HotPoint institution(s)
Center for Computational Biology and Bioinformatics, and College of Engineering, Koc University, Rumelifeneri Yolu, Sariyer Istanbul, Turkey
HotPoint funding source(s)
Supported by TUBITAK (Research Grant No 109T343 and 109E207) and TUBITAK fellowship.

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