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Publications for HotRegion
Understanding Insulin Endocrinology in Decapod Crustacea: Molecular Modelling Characterization of an Insulin Binding Protein and Insulin Like Peptides in the Eastern Spiny Lobster, Sagmariasus verreauxi
[…] clab (http://cpclab.uni-duesseldorf.de/dsppi/) ; Robetta (http://www.robetta.org/alascansubmit.jsp) ; KFC (http://kfc.mitchell-lab.org/) ; ANCHOR (http://structure.pitt.edu/anchor/upload/); and HotRegion (http://prism.ccbb.ku.edu.tr/hotregion/) . In addition, the electrostatic interaction of each Sv complex, Cq-IGFBP_N’ and a range of vertebrate structures was determined by performing elec […]
Enriching Traditional Protein protein Interaction Networks with Alternative Conformations of Proteins
[…] PN is represented in Fig. . This complex protein structure has the global binding energy of −49.82 based on the Fiberdock webserver, . To detect the binding residues in this complex structure we used HotRegion webserver. The binding residues of this complex structure are listed in Supplementary Table , and they are indicated with opaque colours in the figure. We used UCSF Chimera package for molec […]
The Structural Pathway of Interleukin 1 (IL 1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer
[…] inding free energy function , . We accept a threshold of −10 energy units for a favorable interaction . The detection of computational hot spot residues that are used in the analyses is done by using HotRegion Server . […]
Characterizing Changes in the Rate of Protein Protein Dissociation upon Interface Mutation Using Hotspot Energy and Organization
[…] ithin hotregions assumption) and HSEner_NegCoop (negative cooperativity within hotregions assumption) suggests that applying the general assumption of positive cooperativity between hotspots within a hotregion, and accounting for it, provides higher detection rates of stabilizing mutations (i.e. Δlog10(koff)<−1). It should be noted however, that out of the three hotspot predictors which generate t […]
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