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HotRegion specifications


Unique identifier OMICS_02904
Name HotRegion
Restrictions to use None
Maintained Yes

Publications for HotRegion

HotRegion citations


Understanding Insulin Endocrinology in Decapod Crustacea: Molecular Modelling Characterization of an Insulin Binding Protein and Insulin Like Peptides in the Eastern Spiny Lobster, Sagmariasus verreauxi

Int J Mol Sci
PMCID: 5618481
PMID: 28832524
DOI: 10.3390/ijms18091832
call_split See protocol

[…] clab ( []; Robetta ( []; KFC ( []; ANCHOR (; and HotRegion ( []. In addition, the electrostatic interaction of each Sv complex, Cq-IGFBP_N’ and a range of vertebrate structures was determined by performing elec […]


Enriching Traditional Protein protein Interaction Networks with Alternative Conformations of Proteins

Sci Rep
PMCID: 5543104
PMID: 28775330
DOI: 10.1038/s41598-017-07351-0

[…] PN is represented in Fig. . This complex protein structure has the global binding energy of −49.82 based on the Fiberdock webserver, . To detect the binding residues in this complex structure we used HotRegion webserver. The binding residues of this complex structure are listed in Supplementary Table , and they are indicated with opaque colours in the figure. We used UCSF Chimera package for molec […]


The Structural Pathway of Interleukin 1 (IL 1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer

PLoS Comput Biol
PMCID: 3923659
PMID: 24550720
DOI: 10.1371/journal.pcbi.1003470

[…] inding free energy function , . We accept a threshold of −10 energy units for a favorable interaction . The detection of computational hot spot residues that are used in the analyses is done by using HotRegion Server . […]


Characterizing Changes in the Rate of Protein Protein Dissociation upon Interface Mutation Using Hotspot Energy and Organization

PLoS Comput Biol
PMCID: 3764008
PMID: 24039569
DOI: 10.1371/journal.pcbi.1003216

[…] ithin hotregions assumption) and HSEner_NegCoop (negative cooperativity within hotregions assumption) suggests that applying the general assumption of positive cooperativity between hotspots within a hotregion, and accounting for it, provides higher detection rates of stabilizing mutations (i.e. Δlog10(koff)<−1). It should be noted however, that out of the three hotspot predictors which generate t […]


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HotRegion institution(s)
Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, Rumelifeneri Yolu, Istanbul, Turkey

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