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Hotspot Hunter specifications


Unique identifier OMICS_11283
Name Hotspot Hunter
Interface Web user interface
Restrictions to use None
Input data Users can predict hotspots from a single protein sequence, or from a set of aligned protein sequences representing pathogen proteome. The latter feature provides a global view of the localizations of the hotspots in the proteome set, enabling analysis of antigenic diversity and shift of hotspots across protein variants.
Computer skills Basic
Stability No
Maintained No


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Publication for Hotspot Hunter

Hotspot Hunter citations


Mapping HLA A2, A3 and B7 supertype restricted T cell epitopes in the ebolavirus proteome

BMC Genomics
PMCID: 5780746
PMID: 29363421
DOI: 10.1186/s12864-017-4328-8

[…] thms for the prediction of HLA binding peptides [–], and allow the prediction for a wide range of HLA alleles. Prediction in the context of HLA supertypes is offered by a number of the tools, such as Hotspot Hunter [], MAPPP [], MULTIPRED2 [], PEPVAC [], and NetMHC [], among others. Earlier studies had elucidated putative T-cell epitopes of individual EBOV proteins [–] by use of bioinformatics too […]


Characterization of HIV Specific CD4+ T Cell Responses against Peptides Selected with Broad Population and Pathogen Coverage

PLoS One
PMCID: 3390319
PMID: 22792193
DOI: 10.1371/journal.pone.0039874

[…] A diversity. For instance, the Mosaic Vaccine Tool Suite constructs a mosaic protein sequence so that most viral strains are covered ignoring the aspects of the HLA diversity. On the other hand, the Hotspot Hunter method identifies peptides with promiscuous binding to multiple HLA molecules ignoring the HIV genomic diversity.We have previously identified broadly reactive HIV-specific CD8+ T cell […]


Bioinformatics research in the Asia Pacific: a 2007 update

BMC Bioinformatics
PMCID: 2259402
PMID: 18315840
DOI: 10.1186/1471-2105-9-S1-S1

[…] In the global fight against disease, host-pathogen complementarity has been analysed using the AVANA system [] for mutual information analysis, while the HotSpot Hunter [] web service performs large-scale screening and selection of candidate immunological hotspots in pathogen proteomes. […]


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Hotspot Hunter institution(s)
Institute for Infocomm Research, Singapore; School of Computer Engineering, Nanyang Technological University, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Product Evaluation and Registration Division, Centre for Drug Administration, Health Sciences Authority, Singapore; Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA; School of Land, Crop, and Food Sciences, University of Queensland, Brisbame, Australia
Hotspot Hunter funding source(s)
This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, USA, under Grant No. 5 U19 AI56541 and Contract No. HHSN2662-00400085C; and the ImmunoGrid project under the EC contract FP6-2004-IST-4, No. 028069.

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