Hotspot3D statistics

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Citations per year

Citations chart

Popular tool citations

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Tool usage distribution map

Tool usage distribution map

Associated diseases

Associated diseases

Hotspot3D specifications


Unique identifier OMICS_15466
Name Hotspot3D
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Perl
Computer skills Advanced
Version 1.1.5
Stability Stable
Maintained Yes



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  • person_outline Li Ding <>

Publication for Hotspot3D

Hotspot3D in publication

PMCID: 5260099
PMID: 28115009
DOI: 10.1186/s13073-016-0393-x

[…] interaction interfaces. structman [] annotated the amino acid variations of single-nucleotide polymorphisms (snps) in the context of 3d structures. spacepac [], mutation3d [], hotmaps [], and hotspot3d [] used 3d structures to identify mutational clusters in cancer. these efforts have generated interesting sets of candidate functional mutations and illustrate that many rare driver […]

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Hotspot3D funding source(s)
This work was supported by National Cancer Institute grants R01CA180006 and R01CA178383, National Human Genome Research Institute grant U01HG006517, the US Department of Defense grant PC130118 (W81XWH-14-1-0458), National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK087960, and the Precision Medicine Pathway at the Washington University School of Medicine.

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