Hotspot3D statistics

info info

Citations per year


Tool usage distribution map

info info

Associated diseases


Popular tool citations

chevron_left Variant effect prediction chevron_right
Want to access the full stats & trends on this tool?

Hotspot3D specifications


Unique identifier OMICS_15466
Name Hotspot3D
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Perl
Computer skills Advanced
Version 1.1.5
Stability Stable
Maintained Yes




No version available



  • person_outline Li Ding

Publication for Hotspot3D

Hotspot3D citation


3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

Genome Med
PMCID: 5260099
PMID: 28115009
DOI: 10.1186/s13073-016-0393-x

[…] s this observation: All mutations identified by Mutation3D and most mutations identified by HotMAPS that were shown to be functional in the screen were single-residue hotspots, whereas our method and Hotspot3D were able to identify significantly more of the functional rare mutations. Finally, the Hotspot3D prediction included a considerable number of false positives (false detection rate 32% compa […]

Want to access the full list of citations?
Hotspot3D funding source(s)
This work was supported by National Cancer Institute grants R01CA180006 and R01CA178383, National Human Genome Research Institute grant U01HG006517, the US Department of Defense grant PC130118 (W81XWH-14-1-0458), National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK087960, and the Precision Medicine Pathway at the Washington University School of Medicine.

Hotspot3D reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review Hotspot3D