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Hotspot3D specifications

Information


Unique identifier OMICS_15466
Name Hotspot3D
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Perl
Computer skills Advanced
Version 1.1.5
Stability Stable
Maintained Yes

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Documentation


Maintainer


  • person_outline Li Ding

Publication for Hotspot3D

Hotspot3D citation

library_books

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

2017
Genome Med
PMCID: 5260099
PMID: 28115009
DOI: 10.1186/s13073-016-0393-x

[…] s this observation: All mutations identified by Mutation3D and most mutations identified by HotMAPS that were shown to be functional in the screen were single-residue hotspots, whereas our method and Hotspot3D were able to identify significantly more of the functional rare mutations. Finally, the Hotspot3D prediction included a considerable number of false positives (false detection rate 32% compa […]


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Hotspot3D funding source(s)
This work was supported by National Cancer Institute grants R01CA180006 and R01CA178383, National Human Genome Research Institute grant U01HG006517, the US Department of Defense grant PC130118 (W81XWH-14-1-0458), National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK087960, and the Precision Medicine Pathway at the Washington University School of Medicine.

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