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HPID specifications


Unique identifier OMICS_08967
Alternative name Human Protein Interaction Database
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens

Publication for Human Protein Interaction Database

HPID citations


The Influence of HIV on the Evolution of Mycobacterium tuberculosis

Mol Biol Evol
PMCID: 5455964
PMID: 28369607
DOI: 10.1093/molbev/msx107

[…] ecies interactions were only included if the confidence score was greater than 0.7: a score that is considered to indicate high confidence (). The human–HIV-1 interactions were derived from the HIV-1 Human Protein Interaction Database () by filtering on interactions recorded in at least two publications and with interaction types in one of the following categories as defined in (): modification, d […]


A review on computational systems biology of pathogen–host interactions

Front Microbiol
PMCID: 4391036
PMID: 25914674
DOI: 10.3389/fmicb.2015.00235

[…] only HCV, cataloging the characterized protein interactions for intraviral and virus–human systems. Additionally, it includes information on the structure and functions of HCV proteins (). The HIV-1 Human Protein Interaction Database at NCBI includes the interactions between HIV-1 and human proteins. In its content, the majority of the protein interaction data are indirect (e.g., upregulation, mo […]


Quantitative Proteomics by SWATH MS Reveals Altered Expression of Nucleic Acid Binding and Regulatory Proteins in HIV 1 Infected Macrophages

J Proteome Res
PMCID: 3993959
PMID: 24564501
DOI: 10.1021/pr4012602

[…] dels (designated as “Mix” in Figure C, lane 3). Although 125 of the 420 differentially expressed proteins identified by SWATH-MS are reported to interact with HIV-1 proteins as reported by the HIV-1, Human Protein Interaction Database (indicated by asterisk (*) in ), only 13 proteins from the HIV-1, Human Protein Interaction Database display global differential expression during infection and matc […]


Protein Protein Interaction Detection: Methods and Analysis

Int J Proteomics
PMCID: 3947875
PMID: 24693427
DOI: 10.1155/2014/147648

[…] teraction (MINT) database is another database of experimentally derived PPI data extracted from the literature, with the added element of providing the weight of evidence for each interaction []. The Human Protein Interaction Database (HPID) was designed to provide human protein interaction information precomputed from existing structural and experimental data []. The information Hyperlinked over […]


Preliminary evaluation of the CellFinder literature curation pipeline for gene expression in kidney cells and anatomical parts

PMCID: 3629873
PMID: 23599415
DOI: 10.1093/database/bat020

[…] have tried automatic relationships extraction methods: protein phosphorylation information has been extracted using rule-based pattern templates (), recreation of events has been carried out for the Human Protein Interaction Database (HHPID) database () and revalidation of relationships for the PharmGKB database ().We present the first description of the curation pipeline for the CellFinder datab […]


Data management strategies for multinational large scale systems biology projects

Brief Bioinform
PMCID: 3896927
PMID: 23047157
DOI: 10.1093/bib/bbs064

[…] e lightweight integration extreme. Mashups [] are aggregations of multiple web services, e.g. an aggregation of microarray data with interactions from the human immunodeficiency virus type 1 (HIV-1), Human Protein Interaction Database for investigation of the HIV-1 []. Workflows [, ] can be regarded as a dedicated type of mashup. These techniques depend on the availability of web services, which a […]


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HPID institution(s)
School of Computer Science and Engineering, Inha University, Inchon, Korea; Biomatics Laboratory, Department of Biosystems, KAIST, Daejeon, Korea
HPID funding source(s)
This work was supported by the Ministry of Information and Communication of Korea under grant number IMT2000-C3-4.

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