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HPRD specifications


Unique identifier OMICS_02439
Alternative name Human Protein Reference Database
Restrictions to use Academic or non-commercial use
Database management system PostgreSQL
Community driven Yes
Data access File download, Browse
User data submission Allowed
Version 8.9
Maintained Yes
Wikipedia https://en.wikipedia.org/wiki/Human_Protein_Reference_Database


  • Primates
    • Homo sapiens


  • person_outline Akhilesh Pandey
  • person_outline Keshava Prasad

Publications for Human Protein Reference Database

HPRD citations


NIPS, a 3D network integrated predictor of deleterious protein SAPs, and its application in cancer prognosis

Sci Rep
PMCID: 5902451
PMID: 29662108
DOI: 10.1038/s41598-018-24286-2

[…] The high-quality HINT interactome was used as a background network to measure network topology. The data in HINT were collected from BioGrid, DIP, HPRD, IntAct, iRefWeb, MINT, MIPS, and VisAnt–. Low-quality interactions were filtered and systematically and manually removed; thus, only confident physical interactions remained. The new interaction […]


Upregulated VEGFA and DLL4 act as potential prognostic genes for clear cell renal cell carcinoma

PMCID: 5875410
PMID: 29618931
DOI: 10.2147/OTT.S150565

[…] The intersection of the PPI pairs included in Mentha (http://mentha.uniroma2.it/about.php), BioGRID (https://wiki.thebiogrid.org/), and HPRD (http://www.hprd.org/) databases was taken as background, and then the DEGs were mapped into the background to obtain their PPI pairs. Subsequently, the PPI network for the DEGs was visualized by […]


Completing sparse and disconnected protein protein network by deep learning

BMC Bioinformatics
PMCID: 5863833
PMID: 29566671
DOI: 10.1186/s12859-018-2112-7

[…] er simulating an ancient interactome. Then we predicted PPIs by applying regularized Laplacian kernel to the transition matrix built upon that evolved PPI network. Tested on DIP yeast PPI network and HPRD human PPI network, the results show that our method exhibits competitive advantages over the traditional regularized Laplacian kernel that based on the training network only. The proposed method […]


Bioinformatics analysis of microRNAs related to blood stasis syndrome in diabetes mellitus patients

Biosci Rep
PMCID: 5861324
PMID: 29437903
DOI: 10.1042/BSR20171208

[…] ze biological molecule relationships from the public knowledgebase of biological molecules and signification, including GenBank, EMBL, SwissProt, Gene Ontology, KEGG, BioCarta, GenMapp, mirBase, EPD, HPRD, MIND, BIND, Intact, TRANSFAC, UniGene, dbSNP, OMIM, InterPro, HUGO, MGI, RGD, etc. In addition, the significantly enriched GO annotations were chosen (−log10(P-value) > 5). The predicted targets […]


Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non obstructive azoospermia

PMCID: 5841273
PMID: 29531833
DOI: 10.1038/s41420-018-0033-x

[…] The latest experimentally confirmed human protein–protein interaction (PPI) data are available from the human PPI database (http://www.hprd.org/), which has been widely applied in human PPI network research for various diseases. NetworkAnalyzer (http://www.mpi-inf.mpg.de/) was used to analyze the topological properties of biological […]


Discovery of Cryoprotective Activity in Human Genome Derived Intrinsically Disordered Proteins

Int J Mol Sci
PMCID: 5855623
PMID: 29385704
DOI: 10.3390/ijms19020401

[…] he POODLE suites, we chose 53 candidate sequences predicted to be IDPs. Non-redundant proteins or regions of proteins that were predicted to be disordered with high probability were selected from the human protein reference database (HPRD) []. Then, candidate sequences were selected based on the following requirements being satisfied: (1) sequences should be a whole protein or a whole domain; (2) […]


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HPRD institution(s)
Institute of Bioinformatics, International Tech Park, Bangalore, India; Department of Biotechnology, Kuvempu University, Shankaraghatta, India; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Biological Chemistry Johns Hopkins University, Baltimore, MD, USA; Department of Pathology and Oncology, Johns Hopkins University, Baltimore, MD, USA
HPRD funding source(s)
Supported by The Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 578) and German Bundesministerium fur Bildung und Forschung (ERA-NET grant 0313936C).

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