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HSPD specifications


Unique identifier OMICS_04565
Alternative name Hedgehog Signaling Pathway Database
Restrictions to use None
Maintained No


  • Primates
    • Homo sapiens


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Publication for Hedgehog Signaling Pathway Database

HSPD citations


Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER Positive Breast Cancer by a Network Pharmacology Approach

PMCID: 5859839
PMID: 29692855
DOI: 10.1155/2018/5059743

[…] F, and RET. Cluster 3 includes EIF4E, SRC, ERBB4, ESR1, SIRT1, MYB, and PTGS2. Cluster 4 gets PLK1, CTSD, RUNX1, EZH2, TNFRSF11B, NCOA3, GATA3, and MUC1. Cluster 6 has GSTP1 and MKI67. Cluster 7 gets HSPD1, TOP2A, and HDAC4. Cluster 8 includes PIP. These genes may be the key genes of DXP treating ER-positive breast cancer.Deal with these clusters by GO enrichment analysis. Clusters 8, 10, and 11 d […]


Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines

Cell Syst
PMCID: 5747350
PMID: 29226804
DOI: 10.1016/j.cels.2017.11.002

[…] hereas the levels of other chaperones were not consistently decreased (). Phosphopeptides of several proteins involved in protein translation (RPL30, RPS3, and EIF5B) or from chaperones (HSP90AB1 and HSPD1) were affected in their abundance by sterol depletion (; ). Hence, our data confirm a link between cholesterol and proteostasis-related processes and implicate several proteins that are regulate […]


A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma

PMCID: 5739654
PMID: 29285267
DOI: 10.18632/oncotarget.22298

[…] mber of the Ras superfamily of small GTP-binding proteins, HYOU1 (ORP150), which plays a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation, and the heat-shock protein HSPD1 (HSP60). These findings were confirmed by immunoblot analysis, RNAseq UCSC XENA data and q-PCR (Figure ).Network analysis (Figure ) of the proteins identified here by proteomics demonstrated tha […]


Proteome profiling in IL 1β and VEGF activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis

PLoS One
PMCID: 5472280
PMID: 28617818
DOI: 10.1371/journal.pone.0179065

[…] The coexpression network within this module (GO:0001816) centers in quiescent HUVEC around SRGN, POSTN, and HSPD1. The interaction network consists of only 88 proteins with 142 state change controlling interactions and 51 expression controlling interactions. The interaction network centers around HSPD1, a m […]


Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D LC MS/MS Combined with iTRAQ Technology

PMCID: 5332900
PMID: 28261350
DOI: 10.7150/jca.17192

[…] mplex proteins (4.80%). The DEPs were correlated with a wide range of biological processes and molecular functions.As shown in Figure , MS/MS spectra consistent with peptides that are part of DCN and HSPD1. […]


Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

PMCID: 5223607
PMID: 27986797
DOI: 10.1083/jcb.201607110

[…] OP (2895), anti-p38 MAPK (9212), anti–phospho-p38 MAPK (Thr180/Tyr182; 9211), and anti-GAPDH (2118) were obtained from Cell Signaling Technology. Anti-LONP1 (ab103809), anti-CLPP (ab124822), and anti-HSPD1 (ab46798) were purchased from Abcam. Images were scanned on an ODYSSEY instrument and quantitated using Image Studio Software (LI-COR Biosciences). […]


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HSPD institution(s)
Department of biology, Cell and Biology Group and Center for Computing in Life Sciences, San Francisco State University, San Francisco, CA, USA

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