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High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing technologies. This emerging technology provides data for a global analysis of the selection process and for simultaneous discovery of a large number of candidates but currently lacks dedicated computational approaches for their analysis.
(Hoinkaet al., 2015) Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery. Nucleic Acids Res.