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HuGE Navigator specifications


Unique identifier OMICS_07298
Name HuGE Navigator
Restrictions to use None
Version 2.0
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Wei Yu

Publication for HuGE Navigator

HuGE Navigator citations


Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study

PLoS One
PMCID: 5646805
PMID: 29045471
DOI: 10.1371/journal.pone.0186218
call_split See protocol

[…] nd/or DBP in at least one population of European ancestry and were available in the Cardio-Metabochip array (lead SNP or proxy). All the SBP and DBP-associated SNPs were extracted from two databases (HuGE Navigator and NHGRI GWAS Catalog). For SNPs that were not available in the Cardio-Metabochip, we searched for proxy SNPs using the Broad Institute website tool SNAP (SNP Annotation and Proxy Sear […]


CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population

PMCID: 5722548
PMID: 29228596
DOI: 10.18632/oncotarget.21626

[…] total of 29 SNP loci were identified. After extensive review of the literature and information in the National Center for Biotechnology Information SNP database ( SNP) and HuGE Navigator database (, Haploview 4.2 software and the HapMap phase II database were used to obtain four tagged SNPs: rs2236722 (EXON2, missense, c.115T > C, p.Trp39Arg); […]


Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study

Sci Rep
PMCID: 5427872
PMID: 28250428
DOI: 10.1038/s41598-017-00102-1
call_split See protocol

[…] population of European ancestry that were available in the Cardio-Metabochip array. An independent search by S.C. and S.R.d.P. allowed the extraction of the lipid-associated SNPs from two databases (HuGE Navigator and NHGRI GWAS Catalog) or by a manual literature search in the Pubmed database using the following key words: “Genome wide association study”, “lipoprotein cholesterol”, “high-density […]


Genomic structural variations for cardiovascular and metabolic comorbidity

Sci Rep
PMCID: 5264603
PMID: 28120895
DOI: 10.1038/srep41268

[…] nome genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) categories were determined using a hypergeometric statistical test. P-values were corrected for multiple testing using FDR. We also used the HuGE Navigator Database to identify disease-gene association with the cardiovascular diseases.CNVs of interest were validated using TaqMan copy number probes Hs00986678_cn and Hs06959694_cn (Life Tech […]


Identification and Functional Testing of ERCC2 Mutations in a Multi national Cohort of Patients with Familial Breast and Ovarian Cancer

PLoS Genet
PMCID: 4978395
PMID: 27504877
DOI: 10.1371/journal.pgen.1006248

[…] e hundred and ninety targeted genes include 141 genes that code for known proteins involved in DNA repair and DNA damage response pathways, and an additional set of genes retrieved from Phenopedia at HuGE Navigator16 web site associated with “breast neoplasms” (assessed February 2012). Captured libraries were sequenced on SOLiD4 system. Finally, exonic regions of 581 genes were captured successful […]


Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

PMCID: 4971612
PMID: 27579147
DOI: 10.1186/s12263-016-0538-y

[…] omplementary algorithms: Ingenuity (Qiagen, Redwood City, CA), TOPPGene Suite [], and ENDEAVOUR []. For all three algorithms, training gene lists were based on the keyword “PTH” or “Vitamin D” in the HuGE navigator []. Genes were selected if they attained a HuGE score of at least 0.10 and were related to vitamin D and PTH only. Gene names were converted to Ensembl using BioMart Central ID converte […]

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