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Human protein-protein interaction network specifications


Unique identifier OMICS_20693
Name Human protein-protein interaction network
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • person_outline Erich Wanker

Publication for Human protein-protein interaction network

Human protein-protein interaction network citations


Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

BMC Med Genomics
PMCID: 5914069
PMID: 29685133
DOI: 10.1186/s12920-018-0358-6

[…] d pathways are related to DNA replication and cell cycle (Additional file : Table S10). In order to investigate known protein-protein interactions between proteins encoded by the DEGs, we relied on a human protein-protein interaction network published by Li et al. [] based on the extensive human protein interactome from BioGrid []. The authors had identified 817 clusters of densely connected prote […]


Optimizing prognosis related key miRNA target interactions responsible for cancer metastasis

PMCID: 5752539
PMID: 29312626
DOI: 10.18632/oncotarget.22724

[…] GO Terms associated with the hallmarks of cancer were obtained from [, ]. Human protein-protein interaction network (PPI) is obtained from HPRD. Human KEGG pathways from Synapse (syn1741407) which shows the semantic similarity score >0.3 with a hallmark-associated GO term u […]


Functional diversity of topological modules in human protein protein interaction networks

Sci Rep
PMCID: 5701033
PMID: 29170401
DOI: 10.1038/s41598-017-16270-z

[…] We investigated the underlying modular structure in the human protein-protein interaction network derived from STRING9 by adopting seven well-studied community detection algorithms (BGLL, Incremental BGLL (IBGLL), Newman Spectral (NS), Label Propagation (R […]


Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology

Hum Mol Genet
PMCID: 5409085
PMID: 28053046
DOI: 10.1093/hmg/ddw405

[…] by the gene GC content, calculating the residuals from the correlation line obtained for dN/dS and GC content values (), previously calculated using the UCSC galaxy and the EMBOSS tool GEECEE ().The human protein–protein interaction network (PIN) was reconstructed from the interactions available in the BioGRID database version 3.1.81 (). Only non-redundant physical interactions were considered to […]


Personalized anticancer therapy selection using molecular landscape topology and thermodynamics

PMCID: 5386643
PMID: 27793055
DOI: 10.18632/oncotarget.12932

[…] e glioma (LGG) from The Cancer Genome Atlas (TCGA) hosted by the National Institutes of Health (, and well-described in the past []. We focused on the LGG dataset [] of the human protein-protein interaction network (Homo sapiens, 3.3.99, March, 2013) from BioGrid ( containing 9561 nodes and 43,086 edges [, ], and used the adjacency list (i.e. the ma […]


Whole exome sequencing in obsessive compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways

PMCID: 4872454
PMID: 27023170
DOI: 10.1038/tp.2016.30

[…] (). Prioritization is made based on the proximity of interaction (protein–protein interaction) of these seed genes with our WES candidate genes, using the NCBI Entrez Gene Database, which integrates human protein–protein interaction network data from several other databases such as HPRD, BioGRID and BIND. […]


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Human protein-protein interaction network institution(s)
Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany; Max-Planck-Institute for Molecular Genetics, Berlin, Germany; German Genome Resource Center, Heidelberg, Germany
Human protein-protein interaction network funding source(s)
Supported by the German BMBF (NGFN KB-P04T03, 01GR0471; DHGP: 01KW0201; Biofuture: 0311853) and the DFG (SFB577, SFB618, WA1151/5).

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