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HumMod specifications


Unique identifier OMICS_24835
Name HumMod
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C++
License GNU General Public License version 2.0
Computer skills Medium
Version 1.6.1
Stability Stable
Source code URL
Maintained Yes




No version available


  • person_outline Robert Hester <>

Publication for HumMod

HumMod citations


Validation of an integrative mathematical model of dehydration and rehydration in virtual humans

PMCID: 5358000
PMID: 27899683
DOI: 10.14814/phy2.13015

[…] by manipulating vascular tone and regulating water reabsorption in the collecting duct of the kidneys, vasopressin can mediate the retention or loss of fluids quickly. in this study, we validated hummod, an integrative mathematical model of human physiology, against six different challenges to water homeostasis with special attention to the secretion of vasopressin and maintenance […]


A Model of the Cardiorespiratory Response to Aerobic Exercise in Healthy and Heart Failure Conditions

PMCID: 4896934
PMID: 27375488
DOI: 10.3389/fphys.2016.00189

[…] control. cardiovascular-respiratory models have been developed (batzel et al., ; cheng et al., ) but they are not focused on the representation of physical activity phenomena. finally, the hummod (hester et al., ), a model of integrative human physiology, provides a representation of the response of the human body to exercise but its structure is quite complex, as it has been developed […]


The Creation of Surrogate Models for Fast Estimation of Complex Model Outcomes

PMCID: 4892541
PMID: 27258010
DOI: 10.1371/journal.pone.0156574

[…] interests: rh owns hc simulation, which owns all license rights for hummod. this (the ownership of hc simulations by rh) did not alter the authors' adherence to plos one policies on sharing data and materials., conceived and designed the experiments: wp rh. performed […]


A computational analysis of the long term regulation of arterial pressure

PMCID: 3886803
PMID: 24555102
DOI: 10.12688/f1000research.2-208.v2

[…] system in its physiological entirety, including high-level interactions such as an integrated cv and renal system., many versions, declinations (and improvements) do exist, including the late hummod ( hester et al, 2011 should perhaps be cited, instead of abran et al., 2007, since it is the current evolution of qcp/qhp). however, as mentioned by the authors, for various reasons […]


A Population Model of Integrative Cardiovascular Physiology

PMCID: 3772858
PMID: 24058546
DOI: 10.1371/journal.pone.0074329

[…] automata with adaptive step size. it is composed of 4 modules: blood flow autoregulation, baroreceptor reflex, renal control of fluid homeostasis, and cardiac integration. it was programmed in the hummod schema and solved using the model_solver software developed by tom coleman and available for download at the model and its accompanying files can be downloaded […]

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HumMod institution(s)
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA; University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Romani
HumMod funding source(s)
Supported by a NSF EPSCoR grant, National Institutes of Health grant HL-51971, NASA and by NIH 1T32HL105324.

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