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HumMod specifications


Unique identifier OMICS_24835
Name HumMod
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C++
License GNU General Public License version 2.0
Computer skills Medium
Version 1.6.1
Stability Stable
Source code URL
Maintained Yes




No version available


  • person_outline Robert Hester

Publication for HumMod

HumMod citations


Validation of an integrative mathematical model of dehydration and rehydration in virtual humans

PMCID: 5358000
PMID: 27899683
DOI: 10.14814/phy2.13015

[…] re primarily resting during their observation period so renal and hepatic blood flows are left near baseline. GFR, RPF (renal plasma flow), and HPF (hepatic plasma flow) (all in mL) are calculated by HumMod as functions of other systemic factors. The sum of these clearance yields the total clearance of AVP. […]


A Model of the Cardiorespiratory Response to Aerobic Exercise in Healthy and Heart Failure Conditions

Front Physiol
PMCID: 4896934
PMID: 27375488
DOI: 10.3389/fphys.2016.00189

[…] entilation control. Cardiovascular-respiratory models have been developed (Batzel et al., ; Cheng et al., ) but they are not focused on the representation of physical activity phenomena. Finally, the HumMod (Hester et al., ), a model of integrative human physiology, provides a representation of the response of the human body to exercise but its structure is quite complex, as it has been developed […]


The Creation of Surrogate Models for Fast Estimation of Complex Model Outcomes

PLoS One
PMCID: 4892541
PMID: 27258010
DOI: 10.1371/journal.pone.0156574

[…] erent parameter sets, and the differences between individuals are encoded by their parameters. The original version of this type of modeling was the Guyton/Coleman/Granger model, currently branded as HumMod [, ]. This model is currently comprised of ~8000 variables and parameters describing integrative physiology. Other groups have pursued similar philosophies of modeling, such as the Virtual Phys […]


Preventing and Treating Hypoxia: Using a Physiology Simulator to Demonstrate the Value of Pre Oxygenation and the Futility of Hyperventilation

PMCID: 4532969
PMID: 26283881
DOI: 10.7150/ijms.12077

[…] sed (computer based) training, using programs running mathematically modelled human physiology. As an example, we present a variety of simulation studies using a screen-based physiological simulator, HumMod (Version number 2.0.66, HC Simulation, LLC, The HumMod physiology simulator operates with more than 7,500 variables and parameters,; of which we only present a few in this p […]


Simulation environment and graphical visualization environment: a COPD use case

J Transl Med
PMCID: 4255913
PMID: 25471327
DOI: 10.1186/1479-5876-12-S2-S7

[…] tion results. Chaste is only supported in Linux/Unix platforms. Chaste supports models developed in C++. It does not store data and there is no support of parameter communication between the models.• HumMod [] is a simulation and modelling tool. Models description is represented in XML. HumMod is composed of two modules: model documentation, which contains the XML files that correspond to models d […]


A Population Model of Integrative Cardiovascular Physiology

PLoS One
PMCID: 3772858
PMID: 24058546
DOI: 10.1371/journal.pone.0074329

[…] te automata with adaptive step size. It is composed of 4 modules: blood flow autoregulation, baroreceptor reflex, renal control of fluid homeostasis, and cardiac integration. It was programmed in the HumMod schema and solved using the Model_Solver software developed by Tom Coleman and available for download at The model and its accompanying files can be downloaded at https://github […]


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HumMod institution(s)
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA; University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Romani
HumMod funding source(s)
Supported by a NSF EPSCoR grant, National Institutes of Health grant HL-51971, NASA and by NIH 1T32HL105324.

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