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Hydrogen-deuterium exchange software tools| MS-based untargeted proteomics

Hydrogen-deuterium exchange (HDX) experiments analyzed by mass spectrometry (MS) provide information about the dynamics and the solvent accessibility of protein backbone amide hydrogen atoms.Source text:(Lindner et al., 2014) Hexicon 2: automated…
Start2Fold
Dataset

Start2Fold

A comprehensive collection of carefully curated and classified residue- or…

A comprehensive collection of carefully curated and classified residue- or segment-level data on the folding and/or stability proteins that have been previously investigated by solvent exchange-based…

MEMHDX
Web

MEMHDX Mixed Effects Models for HDX-MS analysis

A web application and an R-package to help users analyze, validate and…

A web application and an R-package to help users analyze, validate and visualize large HDX-MS datasets. MEMHDX is composed of two elements. A statistical tool aids in the validation of the results by…

H-Protection
Web

H-Protection

A web server aimed to predict the degree of amino acid residue protection…

A web server aimed to predict the degree of amino acid residue protection against HD exchange solely from the primary structure of the protein chain under study. On the basis of the amino acid…

Hexicon
Desktop

Hexicon

An automated pipeline for data analysis and visualization. Hexicon employs the…

An automated pipeline for data analysis and visualization. Hexicon employs the sensitive NITPICK peak detection algorithm of its predecessor in a divide-and-conquer strategy and adds new features,…

TOF2H
Desktop

TOF2H

Provides a comprehensive hydrogen-deuterium exchange (HDX) data analysis…

Provides a comprehensive hydrogen-deuterium exchange (HDX) data analysis package. TOF2H has been developed for the processing of LC-MALDI-derived HDX data. Initial data processing is based on…

Hydra
Desktop

Hydra

A software package that supports both traditional and exploratory treatments of…

A software package that supports both traditional and exploratory treatments of H/DX-MS data. Hydra's software architecture tolerates flexible data analysis procedures by allowing the addition…

HDExaminer
Desktop

HDExaminer

Analyzes data from any mass-spectrometry (MS) instrument and get a complete…

Analyzes data from any mass-spectrometry (MS) instrument and get a complete picture of the overall deuteration behaviour of protein. HDExaminer is a cutting-edge software for HDX-MS analysis.

HX-Express
Desktop

HX-Express

A Microsoft Excel-based software for semi-automated analysis of hydrogen…

A Microsoft Excel-based software for semi-automated analysis of hydrogen exchange mass spectrometry data. Any data in (x, y) format can be analyzed or spectral data can be directly imported from…

ExMS
Desktop

ExMS

It automatically scans through high resolution MS data to find the individual…

It automatically scans through high resolution MS data to find the individual isotopic peaks and isotopic envelopes of a list of peptides previously identified by MS/MS. ExMS performs a number of…

HDsite
Desktop

HDsite

An iterative optimization program that integrates recent progress in multiple…

An iterative optimization program that integrates recent progress in multiple peptide acquisition together with previously unexamined isotopic envelope-shape information and a site-resolved…

HDX workbench
Desktop

HDX workbench

An integrated desktop program which facilitates automation, management,…

An integrated desktop program which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be…

HDX-analyzer
Desktop

HDX-analyzer

A statistical analysis software has enabled the accurate evaluation of the…

A statistical analysis software has enabled the accurate evaluation of the changes of protein structure dynamics. The software integrates the graphic visualization and statistical analysis to enable…

HDXFinder
Web

HDXFinder

A web-based application for automatic analysis of H/D MS experimental data.…

A web-based application for automatic analysis of H/D MS experimental data. HDXFinder relies on the high resolution of mass spectrometers to extract all isotopic envelopes before correlating these…

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