HyPPO statistics

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Citations per year

Number of citations per year for the bioinformatics software tool HyPPO

Tool usage distribution map

This map represents all the scientific publications referring to HyPPO per scientific context
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Associated diseases


Popular tool citations

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HyPPO specifications


Unique identifier OMICS_28436
Name HyPPO
Alternative name Hybrid Prediction of Paralogs and Orthologs
Software type Framework/Library, Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Input data A set of gene sequences.
Output format FASTA
Operating system Unix/Linux
Programming languages C, C++, Perl, Python
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Manuel Lafond
  • person_outline Mona Meghdari Miardan
  • person_outline David Sankoff

Publication for Hybrid Prediction of Paralogs and Orthologs

HyPPO citations


Unsuccessful mitosis in multicellular tumour spheroids

PMCID: 5438690
PMID: 28430635
DOI: 10.18632/oncotarget.15673

[…] thus responsible for the increase of binucleated cells. Conversely to what was reported for 2D-culture, cytokinesis failure did not induce the stabilisation of p53 and presumably did not activate the hyppo tumour suppressor pathway [, ]. In spite of these unsuccessful mitoses, free floating spheroids are a valuable system for evaluating mitotic drugs even when these drugs target late events.Cytoki […]


Activation of Toll Like Receptors 2 by High Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke

PMCID: 4983677
PMID: 27040385
DOI: 10.7508/ibj.2016.04.006

[…] LR4 is also independently related to lesion volume[,].TLR2 signaling is stimulated in response to host-derived molecules, including gp96 HMGB1, and possibly to larger hydrophobic molecular complexes (Hyppo’s)[]. Investigations have shown that a variety of endogenous ligands, such as HMGB1, are expressed by damaged brain cells[,]. In a study, it has been revealed that dying glioma cells release HMG […]


HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

PLoS Med
PMCID: 2621261
PMID: 19143470
DOI: 10.1371/journal.pmed.1000010

[…] be stimulated in response to host-derived molecules including gp96 [,], HMGB1 [], low molecular weight hyaluronan fragments [], soluble CD14 [,], and possibly larger hydrophobic molecular complexes (Hyppo's) []. Many of these endogenous ligands, such as HMGB1 [], CD14 [], and HSP70 [], are expressed by brain tumor cells. Here we show that dying glioma cells released HMGB1, as a result of infectio […]

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HyPPO institution(s)
Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada; Department of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada
HyPPO funding source(s)
Supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

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