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HyPPO specifications


Unique identifier OMICS_28436
Name HyPPO
Alternative name Hybrid Prediction of Paralogs and Orthologs
Software type Framework/Library, Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Input data A set of gene sequences.
Output format FASTA
Operating system Unix/Linux
Programming languages C, C++, Perl, Python
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Manuel Lafond
  • person_outline Mona Meghdari Miardan
  • person_outline David Sankoff

Publication for Hybrid Prediction of Paralogs and Orthologs

HyPPO citations


Unsuccessful mitosis in multicellular tumour spheroids

PMCID: 5438690
PMID: 28430635
DOI: 10.18632/oncotarget.15673

[…] thus responsible for the increase of binucleated cells. Conversely to what was reported for 2D-culture, cytokinesis failure did not induce the stabilisation of p53 and presumably did not activate the hyppo tumour suppressor pathway [, ]. In spite of these unsuccessful mitoses, free floating spheroids are a valuable system for evaluating mitotic drugs even when these drugs target late events.Cytoki […]


Activation of Toll Like Receptors 2 by High Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke

PMCID: 4983677
PMID: 27040385
DOI: 10.7508/ibj.2016.04.006

[…] LR4 is also independently related to lesion volume[,].TLR2 signaling is stimulated in response to host-derived molecules, including gp96 HMGB1, and possibly to larger hydrophobic molecular complexes (Hyppo’s)[]. Investigations have shown that a variety of endogenous ligands, such as HMGB1, are expressed by damaged brain cells[,]. In a study, it has been revealed that dying glioma cells release HMG […]


HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

PLoS Med
PMCID: 2621261
PMID: 19143470
DOI: 10.1371/journal.pmed.1000010

[…] be stimulated in response to host-derived molecules including gp96 [,], HMGB1 [], low molecular weight hyaluronan fragments [], soluble CD14 [,], and possibly larger hydrophobic molecular complexes (Hyppo's) []. Many of these endogenous ligands, such as HMGB1 [], CD14 [], and HSP70 [], are expressed by brain tumor cells. Here we show that dying glioma cells released HMGB1, as a result of infectio […]


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HyPPO institution(s)
Department of Mathematics and Statistics, University of Ottawa, Ottawa, ON, Canada; Department of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada
HyPPO funding source(s)
Supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

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