I-TASSER statistics

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Citations per year

Number of citations per year for the bioinformatics software tool I-TASSER
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Tool usage distribution map

This map represents all the scientific publications referring to I-TASSER per scientific context
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Associated diseases

This word cloud represents I-TASSER usage per disease context
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Popular tool citations

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Protocols

I-TASSER specifications

Information


Unique identifier OMICS_08046
Name I-TASSER
Alternative name Iterative Threading ASSEmbly Refinement
Interface Web user interface
Restrictions to use None
Input data The primary amino acid sequence of the query protein.
Input format FASTA
Output data A summary of the submitted sequence and local structural feature prediction, the top 10 threading templates used, the top-ranked 3D structure models with global and local accuracy estimations, the top 10 proteins with similar structures to the query and structure-based function annotations on ligand-binding site, EC number and GO term.
Computer skills Basic
Version 4.3
Stability Stable
Requirements
COACH, COFACTOR, LOMET, SPICKER, ModRefiner,
Maintained Yes

Subtools


  • EC number & GO term prediction
  • MUSTER
  • S-SITE
  • TM-SITE

Maintainers


  • person_outline Yang Zhang
  • person_outline Jianyi Yang

Information


Unique identifier OMICS_08046
Name I-TASSER
Alternative name Iterative Threading ASSEmbly Refinement
Software type Toolkit/Suite
Interface Command line interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux
Version 5.1
Stability Stable
Registration required Yes

Subtools


  • EC number & GO term prediction
  • MUSTER
  • S-SITE
  • TM-SITE

Versioning


No version available

Maintainers


This tool is not maintained anymore.

Publications for Iterative Threading ASSEmbly Refinement

I-TASSER citations

 (1196)
call_split

Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6

2018
PMCID: 5930436
PMID: 29716651
DOI: 10.1186/s12964-018-0231-4
call_split See protocol

[…] structure was built using homology modelling. Protein BLAST in eukaryotic genomes was carried out to analyse the sequence homology and identity. Homology modelling of Alpha tubulin was carried out by I-TASSER, an online webserver for protein structure prediction and structure-based function annotation []. The tertiary structure prediction was performed by I-TASSER server by using the best align te […]

library_books

CHRNE compound heterozygous mutations in congenital myasthenic syndrome

2018
PMCID: 5944527
PMID: 29702980
DOI: 10.1097/MD.0000000000010347

[…] The I-TASSER Suite pipeline consists of 4 general steps: threading template identification, iterative structure assembly simulation, model selection and refinement, and structure-based function annotation […]

library_books

Computational Protein Phenotype Characterization of IL10RA Mutations Causative to Early Onset Inflammatory Bowel Disease (IBD)

2018
Front Genet
PMCID: 5934427
PMID: 29755507
DOI: 10.3389/fgene.2018.00146

[…] Though, the PDB sourced IL10RA (1Y6K; 22–235 residues) had sequence homology to build a 3D model, it was of partial length. For this reason we constructed 3D models of IL10RA by using I-Tasser web server (Figure ). A total of five structures were predicted for IL10RA. Only best structures were selected based on their maximum C-score (−3.64), TM-scores (0.32 ± 0.10) which reflects t […]

library_books

Identification of a novel fused gene family implicates convergent evolution in eukaryotic calcium signaling

2018
BMC Genomics
PMCID: 5924475
PMID: 29703146
DOI: 10.1186/s12864-018-4685-y

[…] atabase and the Pfam domain database using SMART software []. Motifs were predicted by MEME (meme-suite.org). The three-dimensional structure of the SCAMK protein was de novo modeled using the online I-TASSER server []. Protein-ligand docking was modeled relying on online server SwissDock []. […]

call_split

Interaction of the GntR family transcription factor Sll1961 with thioredoxin in the cyanobacterium Synechocystis sp. PCC 6803

2018
Sci Rep
PMCID: 5923263
PMID: 29703909
DOI: 10.1038/s41598-018-25077-5
call_split See protocol

[…] the Sll1961-TrxM complex is summarized in Supplementary Fig.  and described in detail in Supplementary Text and Supplementary Table . Three-dimensional structure predictions were performed using the I-TASSER server. Docking predictions were performed using the ZDOCK server. Foldit Standalone was used for manual refinement of predicted structures. […]

call_split

A Legionella pneumophila amylase is essential for intracellular replication in human macrophages and amoebae

2018
Sci Rep
PMCID: 5910436
PMID: 29679057
DOI: 10.1038/s41598-018-24724-1
call_split See protocol

[…] dd/wrpsb.cgi). Phylogenetic analysis was determined using amino acid sequences of LamB, with the Phyologeny.fr platform. Branch length was determined by aLRT,. Predicted structures were generated via I-TASSER (https://zhanglab.ccmb.med.umich.edu/I-TASSER/). Structures generated from I-TASSER were aligned using TM-align to generate a TM-score of structural similarity (https://zhanglab.ccmb.med.umic […]


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I-TASSER institution(s)
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

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