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I2D specifications


Unique identifier OMICS_02910
Name I2D
Alternative name Interologous Interaction Database
Restrictions to use Academic or non-commercial use
Maintained Yes


  • Primates
    • Homo sapiens

Publication for Interologous Interaction Database

I2D citations


Correlates of evolutionary rates in the murine sperm proteome

BMC Evol Biol
PMCID: 5870804
PMID: 29580206
DOI: 10.1186/s12862-018-1157-6

[…] cutoff of 80 in FASTA (for more details, see supplementary methods of []).Numbers of direct and indirect PPI partners relating to Swiss-Prot accession numbers were extracted from downloadable data of I2D (Interologous Interaction Database; http://ophid.utoronto.ca/; []) version 2.9 (for details, see Additional file : Supplementary Methods).For each gene, the tissue specificity index τ [] and the m […]


Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer

PMCID: 5884642
PMID: 29643987
DOI: 10.18632/oncotarget.24337

[…] set and included, the Human Integrated Protein-Protein Interaction rEference (HIPPIE) (updated 9/1/2015; []), Human Protein Reference Database (HPRD Release 9; []), Interlogous Interaction Database (I2D version 2.9; [, ]), PhosphoSitePlus (phosphosite.org - downloaded 10/15/2015; []) and Reactome protein-protein interactions (downloaded 12/15/2015; []). Out of the 254 kinases in the MIB data set, […]


A Novel Phosphorylation Site Kinase Network Based Method for the Accurate Prediction of Kinase Substrate Relationships

Biomed Res Int
PMCID: 5660750
PMID: 29312990
DOI: 10.1155/2017/1826496

[…] the proposed method in further work. Moreover, the PPI dataset used in this study is from STRING database, and there are many other PPI databases that are publicly available, for example, MINT [] and I2D [], which can be included to further improve the performance of the proposed method. Furthermore, as kinase catalyzed phosphorylation site is a complex biological process affected by various mecha […]


Strength of functional signature correlates with effect size in autism

Genome Med
PMCID: 5501949
PMID: 28687074
DOI: 10.1186/s13073-017-0455-8

[…] um path length between two proteins as the weighted edge, with a maximum distance of six jumps roughly as described in Gillis and Pavlidis []. We repeated this for alternative PPI datasets including: I2D [] (v2.9), HPRD [] (release 9), HIPPIE [] (v1.8), IntAct [], the CCSB interactome database [] (HI-III v2.2), STRING [] (v10), and PIPs []. A non-interacting PPI network was created from data from […]


HABP2 p.G534E variant in patients with family history of thyroid and breast cancer

PMCID: 5522276
PMID: 28402931
DOI: 10.18632/oncotarget.16639

[…] rk analysis. Pathways enrichment analysis was performed using KOBAS 2.0 tool []. Selected variants were then used to identify biological context by querying protein-protein interaction (PPI) database Interologous Interaction Database v. 2016-03 [] (http://ophid.utoronto.ca/iid). The resulting network was visualized in NAViGaTOR v3 [] (http://ophid.utoronto.ca/navigator).To elucidate biological fun […]


On the performance of de novo pathway enrichment

NPJ Syst Biol Appl
PMCID: 5445589
PMID: 28649433
DOI: 10.1038/s41540-017-0007-2

[…] Consistently across the two tested networks (HPRD and I2D), BioNet, COSINE, GXNA, and PinnacleZ performed better with expression data generated using VM as compared to VV. DEGAS yielded better results with VV, while the performance of KPM and GiGA was in […]


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I2D institution(s)
Department of Medical Biophysics, University of Toronto, Toronto, Canada

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