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Makes available annotations of RNAi phenotypes, which were gathered in a large scale RNAi screen in the red flour beetle Tribolium castaneum (iBeetle screen). In addition, it provides access to sequence information and links for all Tribolium castaneum genes. The iBeetle-Base contains the annotations of phenotypes of several thousands of genes knocked down during embryonic and metamorphic epidermis and muscle development in addition to phenotypes linked to oogenesis and stink gland biology. The phenotypes are described according to the EQM (entity, quality, modifier) system using controlled vocabularies and the Tribolium morphological ontology (TrOn). Furthermore, images linked to the respective annotations are provided. The data are searchable either for specific phenotypes using a complex 'search for morphological defects' or a 'quick search' for gene names and IDs. iBeetle-Base is the first and currently only resource giving access to RNAi phenotypes gathered in an hypothesis independent way in any insect outside Drosophila.

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iBeetle-Base classification

  • Animals

iBeetle-Base specifications

Restrictions to use:
None
Data access:
Web user interface

Credits

Publications

  • (Donitz et al., 2014) iBeetle-Base: a database for RNAi phenotypes in the red flour beetle Tribolium castaneum. Nucleic acids research.
    PMID: 25378303

Institution(s)

Johann-Friedrich-Blumenbach Institute of Zoology and Anthropology, GZMB, Department of Evolutionary Developmental Genetics, Georg-August-University Göttingen, 37075 Göttingen, Germany; Institute of Microbiology and Genetics, Department of Bioinformatics, Georg-August-University Göttingen, 37073 Göttingen, Germany; Department of Biology, Friedrich-Alexander University, 91058 Erlangen, Germany; Institute for Mathematics and Computer Science, Ernst Moritz Arndt University, 17487 Greifswald, Germany

Funding source(s)

German Research Foundation (DFG) [BU1443/6-1]

Link to literature

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