IC50-to-Ki converter statistics

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Number of citations per year for the bioinformatics software tool IC50-to-Ki converter

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This map represents all the scientific publications referring to IC50-to-Ki converter per scientific context
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IC50-to-Ki converter specifications


Unique identifier OMICS_24610
Name IC50-to-Ki converter
Interface Web user interface
Restrictions to use None
Input data Total concentrations of the enzyme (or target molecule) and substrate (or ligand), the Km of the enzyme-substrate (or the Kd of the target-ligand) reaction and the IC50 value.
Output data Tabulations of the Ki values under different kinetic schemes, extensive tabulations of the results, summary histograms and the corresponding equations.
Database management system Oracle
Computer skills Basic
Stability Stable
Maintained No

Publication for IC50-to-Ki converter

IC50-to-Ki converter citations


In silico structure based screening of versatile P glycoprotein inhibitors using polynomial empirical scoring functions

PMCID: 3969253
PMID: 24711707
DOI: 10.2147/AABC.S56046

[…] osely as possible to a training set composed of hundreds of co-crystallized protein–ligand complexes. The weights obtained from this training set were used to build appropriate POLSCORE functions.The IC50-to-Ki converter was used to compute Ki values from experimentally determined IC50 values for inhibitors of proteins and enzymes that obey classic Michaelis-Menten kinetics of protein–ligand inter […]


Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI 1

PLoS One
PMCID: 3934894
PMID: 24586798
DOI: 10.1371/journal.pone.0089465

[…] the GraFit software package). Human 20S concentration was kept constant at 3.57 nm. Substrate concentrations were varied from 10.8 to 173.4 µm. The remaining Ki values were calculated using an online IC50-to-Ki converter tool (BotDB Database ), assuming competitive inhibition, according to the following relationship: IC50 = Ki(1+ S/Km). Association constants Ka were measured as described previousl […]

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IC50-to-Ki converter institution(s)
Advanced Biomedical Computing Center, Advanced Technology Program, SAIC-Frederick Inc., Frederick, MD, USA; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD, USA
IC50-to-Ki converter funding source(s)
Supported by The Defense Threat Reduction Agency Joint Science and Technology Office-Chemical Biological Defense (project 3.10043_07_RD_B); and by the National Cancer Institute, National Institutes of Health (contract No. HHSN261200800001E).

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