An ontological framework to annotate the electrophysiological class of ion channels. ICEPO is the translation of quantitative assertions extracted through text mining to a formal representation that may help in constructing ontology for ion channel events. The ICEPO ontology is an outcome based on three approaches: i) anecdotal and domain knowledge of the authors, ii) relations extracted from the biomedical text both abstracts and full-text articles, and iii) integration of vocabularies from other existing ontologies. ICEPO focuses on the description of the biophysical properties of voltage-gated ion channels. Ion channels are classified according to either the type of ions for which they are permeable, their three-dimensional structure or the type of stimulus that triggers their activation gating.
CALIPHO Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland; University of Bern, Bern, Switzerland; Department of Human Protein Science, University of Geneva Medical School, Geneva, Switzerland
ICEPO funding source(s)
This work was supported by the National Science Foundation and the National Library of Medicine.