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ICON specifications


Unique identifier OMICS_20562
Alternative names ICON-GPU, ICON-MIC
Software type Framework/Library, Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Version 1.7.2
Stability Stable
Maintained Yes




No version available



  • person_outline Fei Sun
  • person_outline Fa Zhang
  • person_outline Zhiyong Liu

Publications for ICON

ICON citations


Three dimensional structural dynamics of DNA origami Bennett linkages using individual particle electron tomography

Nat Commun
PMCID: 5807444
PMID: 29426880
DOI: 10.1038/s41467-018-03018-0

[…] steriori expectation maximization was used to compensate the missing-wedge effects by Ruotsalainen et al.. An iterative compressed-sensing optimized non-uniform fast Fourier transform reconstruction (ICON) for missing-wedge restoration was proposed by Sun et al.. Moreover, a generalized Fourier iterative reconstruction algorithm (GENFIRE) proposed by Miao and colleagues showed a certain capability […]


The advent of structural biology in situ by single particle cryo electron tomography

Biophysics Rep
PMCID: 5516000
PMID: 28781998
DOI: 10.1007/s41048-017-0040-0

[…] is et al. ; Leary et al. ). Variations of this method have also been demonstrated for cryoET specimens (Aganj et al. ; Song et al. ). Recently, the iterative compressed-sensing optimized non-uniform (ICON) reconstruction (Deng et al. ) method demonstrated that CS can restore missing information in noisy cryoET data of both cells and isolated macromolecules, thereby minimizing missing wedge artifac […]


Biological cryo‐electron microscopy in China

PMCID: 5192968
PMID: 27534377
DOI: 10.1002/pro.3018

[…] iducial marker‐based tilt series algorithm MarkerAuto for cryo‐ET. To improve the contrast and quality of ET reconstruction, they developed three different reconstruction algorithms: ASART, FIRT, and ICON. Notably, ICON combines both nonuniform fast Fourier transformation and compressed sensing techniques and significantly recovers the missing information in both the angular intervals and the miss […]


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ICON institution(s)
Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China; National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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