Identifies the types of conotoxins in targeting ion channels. iCTX-Type can become a useful high throughput tool for both basic research and drug development, particularly for in-depth investigation into the mechanisms of ion-channels and developing new drugs to treat chronic pain, epilepsy, spasticity, and cardiovascular diseases, among others. The overall accuracy of 91.07 per cent was achieved by using jack-knife cross-validation.
Key Laboratory for Neuro-Information of Ministry of Education, Center of Bioinformatics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, China; Gordon Life Science Institute, Boston, MA, USA; Department of Physics, School of Sciences Center for Genomics and Computational Biology, Hebei United University, Tangshan, China; Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia
iCTX-Type funding source(s)
Supported by the National Nature Scientific Foundation of China (nos. 61202256, 61301260, and 61100092), the Nature Scientific Foundation of Hebei Province (no. C2013209105), and the Fundamental Research Funds for the Central Universities (nos. ZYGX2012J113 and ZYGX2013J102).