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iDrug specifications


Unique identifier OMICS_12314
Name iDrug
Interface Web user interface
Restrictions to use None
Programming languages Javascript, Python
Database management system MySQL
Computer skills Basic
Stability No
Maintained No



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Publication for iDrug

iDrug in publications

PMCID: 5771035
PMID: 29338735
DOI: 10.1186/s12981-018-0188-9

[…] (time of clinic enrollment interview), fpatient health questionnaire-9, galcohol, smoking and substance involvement screening test, halcohol use disorder identification test-consumption test, idrug use excludes marijuana, jmeasured as total count of depression, drug use, and alcohol use, kmeasured within 12 months, lreference category, in multivariable analyses (table ), persons […]

PMCID: 5762913
PMID: 29321549
DOI: 10.1038/s41598-017-18448-x

[…] were applied in increasing concentrations and allowed to reach a steady state before applying the next higher concentration. half-maximal inhibition was estimated by fitting the normalized currents (idrug/icontrol) with a hill equation of the form y = a1 + ((a2 − a1)/1 + 10 (log k a − [l])*h), where ka is the ligand concentration which results in half maximal block, a refers to asymptotic […]

PMCID: 5746514
PMID: 29302214
DOI: 10.4196/kjpp.2018.22.1.71

[…] a hill coefficient (n) were obtained by fitting concentration dependence data () to the following equation:, i (%)=1/{1+(ic50 /[d])n}(1) , in which i (%) is the percent current inhibition (i (%)=[1−idrug/icontrol]×100) at the test potential and [d] represents various drug concentrations., the current activation curves () were fitted with the boltzmann isotherm equation:, g/gmax=1/{1+exp […]

PMCID: 5768989
PMID: 29358904
DOI: 10.3389/fnmol.2017.00408

[…] end of each experiment. the kir channel currents were measured by subtracting the ba2+-resistant currents from the total current. the response to the test drug was estimated as the current ratio (idrug/icontrol) at –110 mv, which was obtained by dividing the current recorded in the presence of the drug with the equivalent current recorded in the absence of the drug., sertraline hydrochloride, […]

PMCID: 5507780
PMID: 28706455
DOI: 10.4196/kjpp.2017.21.4.415

[…] and the hill coefficient (n) were obtained from concentration-dependent data and fitted to the following hill equation:, f=1/{1+(ic50/[d])n} , where ƒ is the fractional inhibition of current (ƒ=1−idrug/icontrol) at the test potential, and [d] is the drug concentration., a steady-state activation curve was obtained from the tail currents. tail currents were induced by returning to a potential […]

iDrug institution(s)
Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China; School of Information Science and Engineering, East China University of Science and Technology, Shanghai, China; BNLMS, Center for Quantitative Biology, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
iDrug funding source(s)
The 863 Hi-Tech Program of China (grant 2012AA020308), the National Natural Science Foundation of China (grants 81230090, 81222046 and 81230076), the Shanghai Committee of Science and Technology (grant 12401900801), the National S&T Major Project of China (Grants 2013ZX09507004); Shanghai Rising-Star Tracking Program (grant 13QH1401100); and Fok Ying Tung Education Foundation (141035)

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