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Protocols

IEDB specifications

Information


Unique identifier OMICS_05907
Name IEDB
Alternative names Immune Epitope DataBase, IEDB 2.0, IEDB 3.0, IEDB-3D, IEDB-AR
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes

Taxon


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus

Maintainers


  • person_outline Randi Vita
  • person_outline Bjoern Peters
  • person_outline Ward Fleri

Additional information


A collection of tools for the prediction and analysis of immune epitopes is also available at http://tools.iedb.org/main/ .

Publications for Immune Epitope DataBase

IEDB citations

 (308)
call_split

Immune Informatic Analysis and Design of Peptide Vaccine From Multi epitopes Against Corynebacterium pseudotuberculosis

2018
Bioinform Biol Insights
PMCID: 5954444
PMID: 29780242
DOI: 10.1177/1177932218755337
call_split See protocol

[…] (http://www.imtech.res.in/raghava/abcpred), and BCPreds, which are also based on the learning ability of the machine, applies to support vector machines (http://ailab.cs.iastate.edu/bcpreds/) and the Immune Epitope Database and Analysis Resource (IEDB) (http://www.iedb.org/). The epitopes were predicted in different major histocompatibility complex (MHC) class II alleles (Iab, Iad, Ias, Ied, and I […]

library_books

Investigation of immunogenic properties of Hemolin from silkworm, Bombyx mori as carrier protein: an immunoinformatic approach

2018
Sci Rep
PMCID: 5934409
PMID: 29725106
DOI: 10.1038/s41598-018-25374-z

[…] r B-cell epitopes FBCPred is a novel method developed for prediction of B-cell epitopes with flexible length. B-cell discontinuous epitopes prediction of the hemolin was done by ElliPro (http://tools.iedb.org/ellipro/). ElliPro provides the score to each output epitope which described as PI (Protrusion Index) value averaged over each epitope residue. For each epitope residues, the PI value is calc […]

library_books

Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches

2018
PLoS One
PMCID: 5929558
PMID: 29715318
DOI: 10.1371/journal.pone.0196484

[…] licity prediction [], Emini prediction of surface accessibility [], Kolaskar and Tongaonkar’s antigenicity [], Karplus and Schulz Flexibility Prediction were used using an online analysis resource at IEDB (http://www.iedb.org/). ElliPro [] (http://tools.immuneepitope.org/toolsElliPro/) is an integrated tool in an online IEDB server which can predict B-cell epitopes using both structural informatio […]

library_books

Discrimination Between Human Leukocyte Antigen Class I Bound and Co Purified HIV Derived Peptides in Immunopeptidomics Workflows

2018
Front Immunol
PMCID: 5946011
PMID: 29780384
DOI: 10.3389/fimmu.2018.00912

[…] ettings for MHC class I ligands with 1–5 clusters (). For comparison to mass spectrometry-acquired data, known peptide ligands for HLA class I alleles were extracted from the Immune Epitope Database (IEDB). The Los Alamos National Laboratory HIV database QuickAlign Tool was used to map the location of HIV-1-derived peptides in the HIV-1 genome. Graphs were created using GraphPad Prism 7 software ( […]

library_books

Complexity of type specific 56 kDa antigen CD4 T cell epitopes of Orientia tsutsugamushi strains causing scrub typhus in India

2018
PLoS One
PMCID: 5919512
PMID: 29698425
DOI: 10.1371/journal.pone.0196240

[…] found in the respective data sets regardless of the type of amino acid substitutions involved.Independently extracted amino acid sequences for these regions were used to predict the CD4 TCEs with the Immune Epitope Database and Analysis Resource (IEDB) analysis resource consensus tool using IEDB recommended prediction method defaults [, ]. The spacer between VDI and VDII was too small for similar […]

library_books

Heterologous DNA prime protein boost immunization with RecA and FliD offers cross clade protection against leptospiral infection

2018
Sci Rep
PMCID: 5915591
PMID: 29691454
DOI: 10.1038/s41598-018-24674-8

[…] o predict T- cell specific epitopes. Predictions were made for 8–14 mer peptides of MHC I and 15 mer peptides of MHC II for analysis,,. The conservancy of epitopes and antigenicity were determined by Immune Epitope Database Analysis Resource (IEDB) and VaxiJen score. […]

Citations

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IEDB institution(s)
La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, La Jolla, CA, USA; Knocean Inc., Toronto, ON, Canada; Leidos Health, LLC, San Diego, CA, USA; University of California San Diego, Department of Medicine, La Jolla, CA, USA
IEDB funding source(s)
Supported by National Institutes of Health [HHSN272201200010C].

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