Identifies enhancers and their strength by pseudo k-tuple nucleotide composition. iEnhancer-2L is a two-layer predictor. Its 1st layer is to identify whether a query DNA element is of enhancer or not. If the outcome is yes, then the 2nd layer will automatically continue to identify its strength: strong or weak. To our best knowledge, it is the first predictor ever developed that can be also used to classify enhancers according to their strength. Rigorous cross validation tests have indicated that IENHANCER-2L holds very high potential to become a useful tool for genome analysis.
School of Computer Science and Technology, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China
iEnhancer-2L funding source(s)
This work was supported by the National Natural Science Foundation of China (No. 61300112, 61573118 and 61272383), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, the Natural Science Foundation of Guangdong Province (2014A030313695), and National High Technology Research and Development Program of China (863 Program) [2015AA015405].