IgAT statistics

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Citations per year

Number of citations per year for the bioinformatics software tool IgAT
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Tool usage distribution map

This map represents all the scientific publications referring to IgAT per scientific context
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Associated diseases

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Popular tool citations

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Protocols

IgAT specifications

Information


Unique identifier OMICS_33255
Name IgAT
Alternative name Immunoglobulin Analysis Tool
Software type Application/Script
Interface Graphical user interface
Restrictions to use Academic or non-commercial use
Input data The 11 text output files standardly generated by IMGT/HighV-QUEST derived from its analysis of raw 454 sequence data uploaded by the researcher.
Input format CSV
Operating system Windows
Computer skills Medium
Version 1.17
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Michael Zemlin

Publication for Immunoglobulin Analysis Tool

IgAT citations

 (10)
library_books

Immunodeficiency in Bloom’s Syndrome

2017
PMCID: 5742600
PMID: 29098565
DOI: 10.1007/s10875-017-0454-y

[…] IGHA transcripts of the BS patients with healthy controls. The R/S ratio seemed lower in the IGHG transcripts but in the normal range in the IGHA transcripts (Fig. c). Additionally, we also used the Immunoglobulin Analysis tool (IgAT) which calculates for each rearrangement whether it has undergone antigen selection based on the number of replacement mutations in relation to the total number of m […]

library_books

Altered marginal zone and innate like B cells in aged senescence accelerated SAMP8 mice with defective IgG1 responses

2017
PMCID: 5596542
PMID: 28817118
DOI: 10.1038/cddis.2017.351

[…] mgt.org/HighV-QUEST/). Comparative sequence analysis between populations and the complementarity determining region of the antibody heavy chain (CDR-H3) amino-acid alignments were performed using the Immunoglobulin Analysis Tool software, IgAT. Circle graphs were obtained using the available software (http://circos.ca/). […]

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B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis

2017
PMCID: 5473332
PMID: 28343748
DOI: 10.1016/j.jaut.2017.03.004
call_split See protocol

[…] d CDRs were calculated for each region based on the absolute number of V gene nucleotides in all analyzed sequences as defined by IMGT. IgG isotype subclasses were determined using the IMGT database. Immunoglobulin Analysis Tool (IgAT) was used to calculate the probability of antigen-driven selection within the Ig repertoire of the monoclonal antibodies as previously described . […]

library_books

Evaluation of the Antigen Experienced B Cell Receptor Repertoire in Healthy Children and Adults

2016
Front Immunol
PMCID: 5066086
PMID: 27799928
DOI: 10.3389/fimmu.2016.00410

[…] cid locations also confirms an increased frequency of R mutations in the CDR regions (Figure C).In addition to the R/S ratio, several tools have been developed to analyze selection of the repertoire. IgAT looks at the number of R mutations in the CDR in relation to the total number of mutations and uses this to calculate, for each sequence, whether it has undergone antigen selection (). In this de […]

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Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

2015
PMCID: 5036240
PMID: 26659717
DOI: 10.1136/annrheumdis-2015-208356
call_split See protocol

[…] ilent mutation in each Framework Region (FR)/CDR region to determine the R:S ratio. The expression vector cloning strategy and the monoclonal antibody production were performed as described in ref. . Immunoglobulin Analysis Tool (IgAT) software was used to calculate the probability of antigen-driven selection within the Ig repertoire of the RA-rmAbs, as previously described. […]

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Accumulation of Self Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome

2014
PLoS One
PMCID: 4275206
PMID: 25535746
DOI: 10.1371/journal.pone.0114575
call_split See protocol

[…] VH and VL products were used for downstream cloning and recombinant antibody expression. All productive VH and VL products from naïve B cells displayed unmutated germ line sequences (data not shown).Immunoglobulin Analysis Tool (IgAT) software was used to calculate the probability of antigen-driven selection within the Ig repertoire of memory unswitched and switched B cells . IgAT uses the algori […]


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IgAT institution(s)
Department of Pediatrics, Philipps-University Marburg, Marburg, Germany; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Department of Pathology and Microbiology, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE, USA; Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX, USA
IgAT funding source(s)
Supported by the German Research Foundation, SFB/TR22, TPA17.

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