IgDiscover statistics

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Citations per year

Number of citations per year for the bioinformatics software tool IgDiscover

Tool usage distribution map

This map represents all the scientific publications referring to IgDiscover per scientific context
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IgDiscover specifications


Unique identifier OMICS_16456
Name IgDiscover
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data An RNA sequence (raw).
Input format FASTQ, FASTA
Output data A gene expression profile.
Operating system Unix/Linux, Mac OS
Programming languages Python
License MIT License
Computer skills Advanced
Version 0.6.0
Stability Stable
Maintained Yes




No version available


  • person_outline Martin Corcoran

Publication for IgDiscover

IgDiscover citations


Analyzing Immunoglobulin Repertoires

Front Immunol
PMCID: 5861150
PMID: 29593723
DOI: 10.3389/fimmu.2018.00462

[…] ne databases. Humans and mice have the most well defined Ig gene loci, but a map of all allelic variants is not complete (). There have been efforts to address this with algorithms—such as TIgGER (), IgDiscover (), IMPre (), and a more recent allele prediction and validation tool ()—that can be used to identify germline alleles for individual repertoires. Proper identification of non-template addi […]


Computational Strategies for Dissecting the High Dimensional Complexity of Adaptive Immune Repertoires

Front Immunol
PMCID: 5826328
PMID: 29515569
DOI: 10.3389/fimmu.2018.00224

[…] of using one central germline reference database containing a more or less static set of non-personalized germline gene alleles. To address this problem, Corcoran et al. developed a software package (IgDiscover), which employs a cluster identification approach to reconstruct de novo from an AIRR-seq data set the corresponding V-gene germline database—all without a priori knowledge of existing germ […]


Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths

Front Immunol
PMCID: 5694033
PMID: 29180996
DOI: 10.3389/fimmu.2017.01433

[…] The germline gene repertoire of the donors have been inferred using IgDiscover () using the IgM-encoding transcriptomes of the donors’ BM, and has, when possible, been quality controlled by haplotype-based analysis (, ). Eleven commonly expressed germline genes (IGHV1 […]


Env Specific Antibodies in Chronic Infection versus in Vaccination

Front Immunol
PMCID: 5591324
PMID: 28928737
DOI: 10.3389/fimmu.2017.01057

[…] usly appreciated (–). An improved understanding of human antibody germline genes is therefore needed. We recently reported that next-generation sequencing (NGS) coupled with a new computational tool, IgDiscover, can accelerate the definition of germline-encoded Ig gene segments and allow higher-throughput studies ().HIV-1 bNAb sequences stand out not only because of high levels of divergence from […]


Data on haplotype supported immunoglobulin germline gene inference

PMCID: 5502703
PMID: 28725665
DOI: 10.1016/j.dib.2017.06.031
call_split See protocol

[…] ails of sequence output and availability are outlined in . Data was pre-processed using pRESTO and Change-O as summarized in Fig. 1 in Ref. . Germline gene inference was performed using TIgGER and IgDiscover . Additional bioinformatics analysis was performed as outlined elsewhere including analysis performed using GIgGle (release 0.2) that is available under Apache License at https://github.co […]

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IgDiscover funding source(s)
This work was funded by an NIH P01 grant AI104722 (HIVRAD) and a grant from the International AIDS Vaccine Initiative (IAVI), a Karolinska Institutet KID grant, Knut and Alice Wallenberg Foundation to the Wallenberg Advanced Bioinformatics Infrastructure.

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