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Performs error-correction of immunosequencing reads and uses mass spectra to validate the constructed antibody repertoires. IgRepertoireConstructor takes Illumina MiSeq paired end reads as an input and expect that each left and right reads overlap and cover variable region of antibody. IgRepertoireConstructor stitches paired-end reads and removes contaminations using alignment of stitched reads against Ig germline database. This procedure significantly improves quality of input reads and allows one to constructs reads covering variable region of antibody.

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IgRepertoireConstructor classification

IgRepertoireConstructor specifications

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Command line interface
Biological technology:
Programming languages:
C++, Python
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IgRepertoireConstructor distribution


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IgRepertoireConstructor support


  • Pavel A. Pevzner <>


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Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia; Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia; Bioinformatics Program, University of California, San Diego, CA, USA; Genentech, South San Francisco, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, CA, USA

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