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IIS specifications

Information


Unique identifier OMICS_12742
Name IIS
Alternative name Integrated Interactome System
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Gabriela Vaz Meirelles

Publication for Integrated Interactome System

IIS citations

 (7)
library_books

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

2017
Sci Rep
PMCID: 5511132
PMID: 28710492
DOI: 10.1038/s41598-017-05325-w

[…] e and phosphoproteome analyses from the NEK1 IP-LC-MS/MS with or without cisplatin.The retrieved human NEK1 interacting partners from the IP-LC-MS/MS were integrated in interaction networks using the Integrated Interactome System (IIS) platform, developed at National Laboratory of Biosciences, Brazil. The enriched biological processes from the Gene Ontology (GO, http://www.geneontology.org/) datab […]

library_books

From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web resources for mass spectral plant metabolomics

2017
GigaScience
PMCID: 5499862
PMID: 28520864
DOI: 10.1093/gigascience/gix037

[…] ial Molecular Networking; GUI: graphical user interface; HCS: hierarchical cluster analysis; HMDB: Human Metabolome Database; HRMS: high-resolution mass spectrometry; ICT: Isotope Correction Toolbox; IIS: Integrated Interactome System; iMet-Q: Intelligent Metabolomic Quantitation; IMPaLA: Integrated Molecular Pathway Level Analysis; InCroMAP: Integrated Analysis of Cross-Platform Microarray and Pa […]

library_books

The Use of Omic Technologies Applied to Traditional Chinese Medicine Research

2017
PMCID: 5307000
PMID: 28250795
DOI: 10.1155/2017/6359730

[…] ing made to improve the current tools in order to integrate the omic information and generate more reliable and complete bioinformatics tools. An example of such improved bioinformatic options is the Integrated Interactome System which comprises genes, proteins, metabolites, and drugs data []. Together with other bioinformatics tools such as the Human Metabolome Database, BioMagResBank, the Madiso […]

library_books

Interaction network and mass spectrometry data of Xanthomonas citri subsp. citri surface proteins from differential proteomic analysis of infectious and non infectious cells

2016
PMCID: 4995475
PMID: 27595129
DOI: 10.1016/j.dib.2016.07.054

[…] The identified proteins were submitted to an enrichment analysis by Integrated Interactome System (IIS) platform using the functional annotation database of Escherichia coli, since Xanthomonas sp. does not have such database annotation. The resulting protein map was […]

library_books

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing

2015
Proteome Sci
PMCID: 4367857
PMID: 25798074
DOI: 10.1186/s12953-015-0065-6

[…] ned on the subsequent analysis and were discriminated on Additional file and Figure .The retrieved Nek4.1 and Nek4.2 interacting partners from IP-MS were integrated in interaction networks using the Integrated Interactome System (IIS) platform, developed at National Laboratory of Biosciences, Brazil []. The enriched biological processes from the Gene Ontology (GO, http://www.geneontology.org/) da […]

library_books

Characterization of the Human NEK7 Interactome Suggests Catalytic and Regulatory Properties Distinct from Those of NEK6

2014
J Proteome Res
PMCID: 4156247
PMID: 25093993
DOI: 10.1021/pr500437x

[…] To generate NEK7 PPI maps at proteome scale, the retrieved NEK7 interacting proteins from IP-LC–MS/MS and Y2H were integrated in interaction networks using the Integrated Interactome System (IIS) platform, developed at National Laboratory of Biosciences, Brazil (http://www.lge.ibi.unicamp.br/lnbio/IIS/). The enriched biological processes from the Gene Ontolo […]

Citations

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IIS institution(s)
Laboratorio Nacional de Biociencias, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, Sao Paulo, Brazil; Laboratorio de Genomica e Expressao, Departamento de Genetica e Evolucao, Instituto de Biologia, Unicamp, Campinas, Sao Paulo, Brazil; Laboratorio Nacional de Luz Sıncrotron, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, Sao Paulo, Brazil
IIS funding source(s)
This work was supported by Fundacao de Amparo a Pesquisa do Estado Sao Paulo (FAPESP), Conselho Nacional de Pesquisa e Desenvolvimento (CNPq), Brazilian Biosciences National Laboratory (LNBio) and Center for Computational Engineering and Sciences at UNICAMP, Brazil.

IIS review

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Henry Heberle

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Web
You can build protein-protein networks and visualize them using CellNetVis (https://omictools.com/cellnetvis-tool). The nodes are annotated with cellular component, biological processes, and also with selected unique attributes, such as the top cellular component and top BP. With Top Cellular Component CellNetVis is able to give you a good visualization of your network.