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iLIR specifications


Unique identifier OMICS_07888
Name iLIR
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline iLIR Team

Publication for iLIR



2014 Autophagy
PMCID: 5119064
PMID: 24589857
DOI: 10.4161/auto.28260

iLIR citations


Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase

Nat Commun
PMCID: 5871769
PMID: 29593293
DOI: 10.1038/s41467-018-03658-2

[…] Supplementary Fig. ). The NbATG8-interacting domain was mapped to the N-terminal region of NbBeclin1 (NbBeclin1-N) (Fig.  and Supplementary Fig. ). A web-based analysis ( identified a potential ATG8 interacting motif (AIM) in NbBeclin1-N. The NbBeclin1-N AIM mutant (NbBeclin1-NΔAIM) resulting from the replacement of EESFVVL with EESAVVA lost the ability to intera […]


The E3 ubiquitin ligase NEDD4 enhances killing of membrane perturbing intracellular bacteria by promoting autophagy

PMCID: 5788543
PMID: 29251248
DOI: 10.1080/15548627.2017.1376160

[…] as indispensable for interaction with LC3B (). Immunofluorescence also confirmed that the 255–380 region of NEDD4 was required for its colocalization with LC3B (Fig. S5B). In silico analysis with the iLIR web server has identified a putative LC3-interacting region (264-269, ENWEII) within the sequence 256–380 of NEDD4. Indeed, the interaction between NEDD4 with LC3B was abolished by deleting the m […]


Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses

Nat Commun
PMCID: 5668318
PMID: 29097655
DOI: 10.1038/s41467-017-01287-9

[…] In order to identify LC3-interacting region (LIR) motif-containing proteins in Drosophila, we screened the Drosophila proteome for the presence of LIR motifs using the iLIR software that we have developed,. We focused on proteins that also contained ubiquitin-binding domains. One of our hits was the UBAN domain-containing protein Kenny (CG16910) that has a predicted […]


[email protected]: A web resource for LIR motif containing proteins in viruses

PMCID: 5640201
PMID: 28806134
DOI: 10.1080/15548627.2017.1356978

[…] To share the information beyond our MySQL (v5.6.33) DBMS (Database Management System), we built a website using HTML, CSS, JavaScript and PHP (v5.6.27) technologies. It is hosted at Through the website, users can navigate for LIRCPs using both Baltimore and ICTV Virus classification systems. […]


Centriolar Satellites Control GABARAP Ubiquitination and GABARAP Mediated Autophagy

Curr Biol
PMCID: 5526835
PMID: 28712572
DOI: 10.1016/j.cub.2017.06.021

[…] somes (C and 1D). PCM1 bound ATG8 family members LC3C/GABARAP/GABARAPL1/GABARAPL2 but poorly to LC3A/LC3B (E). We searched for LIR motifs in the 2,016aa human PCM1 protein (Refseq NP_001302436) using iLIR []. One LIR motif (aa 1,953-EDFVKV-aa 1,958) near the C terminus of PCM1, within a region required to retain PCM1 at the centrosome [, ], is similar to the human ULK LIR motif (DDFVM/LV) [, ]. Mu […]


Elucidation of the anti autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

PMCID: 5388539
PMID: 28395732
DOI: 10.7554/eLife.23905.037

[…] quite conserved, with two key hydrophobic residues playing an essential role in interaction with the hydrophobic pocket of the Atg8s (; , ). Three potential LIR motifs of RavZ were identified by the iLIR online server () (). The first and second LIR motifs are located at the N-terminal region of RavZ (residues 14–19, LIR1; and 27–32, LIR2), while the third motif is in the C-terminal region (resid […]


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iLIR institution(s)
Bioinformatics Research Laboratory, Department of Biological Sciences; University of Cyprus, Nicosia, Cyprus

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