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iMADS specifications


Unique identifier OMICS_23002
Name iMADS
Alternative name integrative Modeling and Analysis of Differential Specificity
Software type Framework/Library
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Raluca Gordan <>

Publication for integrative Modeling and Analysis of Differential Specificity

iMADS in publications

PMCID: 5581132
PMID: 28881833
DOI: 10.18632/oncotarget.18655

[…] that lncrna h19 in development and stem cell differentiation, we examined the expression patterns of h19 in mscs upon bmp9 stimulation. using the previously well-characterized msc lines imefs and imads [–], we found that at the early stage of bmp9 stimulation (24h and 36h), the expression of h19 increased dramatically and reached a peak at 36h in both imefs and imads cells, compared […]

PMCID: 5661262
PMID: 28470873
DOI: 10.1111/jcmm.13193

[…] using the sv40 t antigen, one of the most commonly used immortalization genes, we have successfully immortalized numerous cell lines, including embryonic fibroblasts , , adipose‐derived mscs (imads) , stem cells from dental apical papilla , mouse melanocytes , hepatic progenitor cells , , , calvarial mesenchymal progenitor cells , articular chondrocytes , foetal heart progenitors […]

PMCID: 5332017
PMID: 28249039
DOI: 10.1371/journal.pone.0172327

[…] is a consistent finding no matter what progenitor cell source we have used in our experimentation—icals [,], immortalized murine embryonic fibroblasts (imefs) [], immortalized murine adipocytes (imads) [], and may represent a differentiation “default” for cells without bmp9 stimulation in the ppcn microenvironment. overall, these results reiterate previous findings from our lab […]

PMCID: 2064080
PMID: 17389229
DOI: 10.1083/jcb.200701048

[…] four times according to a standard protocol (cocalico biologicals, inc.). antibodies were purified with a sulfolink kit (pierce chemical co.) using the original peptide., ovaries were dissected in imads () and fixed in 6% formaldehyde saturated with heptane as previously described (). to visualize f-actin, egg chambers were incubated with 1 u of rhodamine-conjugated phalloidin in pbt. […]

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iMADS institution(s)
Center for Genomic and Computational Biology, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Durham, NC, USA; Durham, NC, USA; Department of Biostatistics and Bioinformatics, Durham, NC, USA; Program in Computational Biology and Bioinformatics, Durham, NC, USA; Department of Computer Science, Duke University, Durham, NC, USA
iMADS funding source(s)
Supported by NSF grant MCB-14-12045, NIH grant R01-GM117106, and an Alfred P. Sloan Foundation fellowship.

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