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iMADS specifications


Unique identifier OMICS_23002
Name iMADS
Alternative name integrative Modeling and Analysis of Differential Specificity
Software type Framework/Library
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Raluca Gordan

Publication for integrative Modeling and Analysis of Differential Specificity

iMADS citations


lncRNA H19 mediates BMP9 induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling

PMCID: 5581132
PMID: 28881833
DOI: 10.18632/oncotarget.18655
call_split See protocol

[…] Mouse mesenchymal stem cell (MSC) lines iMEFs and iMADs are the conditionally immortalized mouse embryonic fibroblasts and immortalized multipotent adipose-derived cells as previously described [–]. 293pTP cells were derived from HEK-293 cells overex […]


BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients

J Cell Mol Med
PMCID: 5661262
PMID: 28470873
DOI: 10.1111/jcmm.13193

[…] neering.Using the SV40 T antigen, one of the most commonly used immortalization genes, we have successfully immortalized numerous cell lines, including embryonic fibroblasts , , adipose‐derived MSCs (iMADs) , stem cells from dental apical papilla , mouse melanocytes , hepatic progenitor cells , , , calvarial mesenchymal progenitor cells , articular chondrocytes , foetal heart progenitors and mous […]


Repair of critical sized cranial defects with BMP9 transduced calvarial cells delivered in a thermoresponsive scaffold

PLoS One
PMCID: 5332017
PMID: 28249039
DOI: 10.1371/journal.pone.0172327

[…] type is a consistent finding no matter what progenitor cell source we have used in our experimentation—iCALs [,], immortalized murine embryonic fibroblasts (iMEFs) [], immortalized murine adipocytes (iMADs) [], and may represent a differentiation “default” for cells without BMP9 stimulation in the PPCN microenvironment. Overall, these results reiterate previous findings from our lab that demonstra […]


Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis

PMCID: 2064080
PMID: 17389229
DOI: 10.1083/jcb.200701048

[…] Ovaries were dissected in IMADS () and fixed in 6% formaldehyde saturated with heptane as previously described (). To visualize F-actin, egg chambers were incubated with 1 U of rhodamine-conjugated phalloidin in PBT. The follo […]

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iMADS institution(s)
Center for Genomic and Computational Biology, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Durham, NC, USA; Durham, NC, USA; Department of Biostatistics and Bioinformatics, Durham, NC, USA; Program in Computational Biology and Bioinformatics, Durham, NC, USA; Department of Computer Science, Duke University, Durham, NC, USA
iMADS funding source(s)
Supported by NSF grant MCB-14-12045, NIH grant R01-GM117106, and an Alfred P. Sloan Foundation fellowship.

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