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Normalization is critically important for the proper interpretation of matrix-assisted laser desorption/ionization (MALDI) imaging datasets. The effects of the commonly used normalization techniques based on total ion count (TIC) or vector norm normalization are significant, and they are frequently beneficial.
(Deininger., 2011) Normalization in MALDI-TOF imaging datasets of proteins: practical considerations. Anal bioanal Chem