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Imaging by mass spectrometry has been generally regarded as a qualitative method with some recent demonstrations of quantitative analyses for small molecules. Fundamentally, the signal provided by MSI is a direct measurement of analyte relative abundance and, therefore, with the use of proper matrices and internal standards it is possible to obtain quantitative data.
(Koeniger., 2011) A quantitation method for mass spectrometry imaging. Rapid Commun Mass Spectrom.