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A “profilometry” framework for the multimetric analysis of white matter tracts. Mrpipe is a statistical framework that combine a multivariate analysis of covariance (MANCOVA) and a linear discriminant analysis (LDA) both accounting for age and gender, with multiple comparison corrections. This methodology can not only combine tract profile analyses in a single statistical model but can also take into account covariates such as age and gender which are of particular importance in most clinical investigations. This project is still a skeleton, the tool is not ready for use.