Defines profiles, signatures, fingerprints of steady-state and activated human immune system. Through the HITC, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods. It creates centralized knowledge base and resources to facilitate investigations of human immunity and develop novel applications for human disease.
Provides evolutionary trees of proteins in the human immune system. ImmTree facilitates queries according to the classic groupings of immune functions, such as humoral immunity, cellular immunity, complement system. It contains information for orthologs of the human genes in 80 species, including all the major model organisms from Eukaryota. This database permits comparison of human-mouse ortholog pairs.
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