Cytokines regulate the immunological activities of lymphocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells and other cell types. The DACS-DB database will help cytokine biologists, immunologists and interested biomedical researchers understand these associations so as to learn about essential disease associated cytokine SNPs.
Defines profiles, signatures, fingerprints of steady-state and activated human immune system. Through the HITC, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods. It creates centralized knowledge base and resources to facilitate investigations of human immunity and develop novel applications for human disease.
Collects information about neuro-endocrine-immune (NEI) systems. dbNEI is a manually curated database that compiles data from about 1000 NEI related signal molecules and their interactions accompanied by affiliated tissues from the Cell Signaling Networks database. Additionally, the repository gives access to science literature and multilayer interactions of NEI molecules with over 600 drugs and 800 diseases to help detect of novel connections between drug and disease.
Collects biological information about the human cytokine receptor families and their related ligands. CytReD provide a review of cytokine receptors, their ligands, their involvement in diseases and their use in clinical treatments. Users can search by “Cytokine”, Receptor Name”, “Ligands”, “Cytokine Family” or “Disease”. The database can be used by researchers as well as physicians and clinicians to identify what cytokines are reported in the literature as significant in a given disease.