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ImmunoBase specifications

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Unique identifier OMICS_17662
Name ImmunoBase
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes

ImmunoBase citations

 (6)
library_books

Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites

2018
Front Genet
PMCID: 5932181
PMID: 29755505
DOI: 10.3389/fgene.2018.00139

[…] rther intersection with summary statistics from GWAS high density genotyped data (Immunochip).We integrated three miRSNPs prediction tools with summary statistics from 12 GWAS of AID available in the Immunobase database (Table ).However, even studies using a dense genotyping custom-made array designed to fine-map immune-related diseases, such as the Immunochip, may still miss associations due to d […]

library_books

Genome wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

2017
Nat Commun
PMCID: 5711884
PMID: 29196614
DOI: 10.1038/s41467-017-00320-1

[…] between cHL and autoimmune disease, we implemented cross-trait LD score regression. Using summary-level GWAS data we estimated genetic correlations between cHL and six autoimmune diseases curated by ImmunoBase; specifically rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), primary biliary cirrhosis, ulcerative colitis (UC) and coeliac disease GWAS data (Supplementary Ta […]

library_books

De novo mutations implicate novel genes in systemic lupus erythematosus

2017
Hum Mol Genet
PMCID: 5886157
PMID: 29177435
DOI: 10.1093/hmg/ddx407

[…] e CADD Phred scores >30, placing them in the top 0.1% of possible damaging mutations in the human genome (). We further explored the function, expression (BioGPS), existing autoimmunity associations (ImmunoBase), and gene-level constraint against missense mutations (ExAC), of the DNM genes to build a profile of a priori evidence of a role in SLE pathogenesis. None of the candidate genes have been […]

library_books

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes

2017
PMCID: 5651267
PMID: 29093700
DOI: 10.3389/fendo.2017.00276

[…] e there have been no experimental systems available to study individual risk variants in human subjects. For T1D, where approximately 57 different genetic regions confer some portion of genetic risk (immunobase.org, July 2017) (, –), it is not possible to study one gene at a time without incurring significant epistatic effects from other risk genes. The likelihood of finding two individuals differ […]

library_books

Common shared genetic variation behind decreased risk of breast cancer in celiac disease

2017
Sci Rep
PMCID: 5517429
PMID: 28725034
DOI: 10.1038/s41598-017-06287-9

[…] s for ER-positive breast cancer risk, and 7,333 ER-negative cases and 42,468 controls for ER-negative breast cancer risk. Summary statistics for celiac disease (133,352 SNPs) were downloaded from the ImmunoBase (https://www.immunobase.org/), a web based resource focused on the genetics and genomics of immunologically related human diseases. Celiac disease data have been reported in a GWAS study by […]

library_books

GWAS of self reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune related predisposition loci

2017
Hum Mol Genet
PMCID: 5390679
PMID: 28199695
DOI: 10.1093/hmg/ddx036

[…] 1000 Genomes Project, http://www.1000genomes.org/; UCSC Genome Browser, http://genome.ucsc.edu/; HaploReg, http://www.broadinstitute.org/mammals/haploreg/haploreg.php; Immunobase, http://www.immunobase.org/page/Welcome/display; BIOCARTA, http://cgap.nci.nih.gov/Pathways/BioCarta_Pathways […]

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