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Immunoglobulin rearrangement identification software tools | Immunoinformatics

B cells express immunoglobulin (Ig) molecules on their outer surface and secrete them into the extracellular space. Secreted Ig is known as antibody. The genes that encode for antibodies are generated by many diversifying mechanisms including…
IMGT/V-QUEST
Web

IMGT/V-QUEST

Identifies and delimits the variable (V), diversity (D) and joining (J) genes…

Identifies and delimits the variable (V), diversity (D) and joining (J) genes and alleles within immunoglobulin (Ig) or T-cell receptor (TR) nucleotide rearranged sequences. IMGT/V-QUEST delimits…

iHMMune-align
Web
Desktop

iHMMune-align

Allows modelling of processes implicated in human immunoglobulin heavy chain…

Allows modelling of processes implicated in human immunoglobulin heavy chain (IGH) gene rearrangement and maturation. iHMMune-align incorporates an explicit model of V-D-J recombination and somatic…

G T A T C G C T A
HTJoinSolver
Desktop
Web

HTJoinSolver

Handles alignments with insertions/deletions (indels), while maintaining or…

Handles alignments with insertions/deletions (indels), while maintaining or improving the speed. HTJOINSOLVER is a desktop application, provided as an implementation of the partitioning method.…

VDJsolver
Web

VDJsolver

Allows to proceed analysis of heavy chain joints. VDJsolver is based on a…

Allows to proceed analysis of heavy chain joints. VDJsolver is based on a maximum-likelihood method which takes the lengths of the joint and the mutational status of the VH gene into account. It has…

Cloanalyst
Desktop

Cloanalyst

Determines the rearrangement of antigen receptor based on somatic genetics of…

Determines the rearrangement of antigen receptor based on somatic genetics of antibodies. Cloanalyst performs Bayesian and basic clonal analysis. The software can be useful for studying antibody…

Ab-origin
Desktop

Ab-origin

Allows identification of sourcing gene segments in germline for rearranged…

Allows identification of sourcing gene segments in germline for rearranged antibodies. Ab-origin is a program based on BLAST that partitions functional antibody sequences to corresponding gene…

SoDA
Web

SoDA Somatic Diversification Analysis

Permits the identification of immunoglobulin rearrangements. SoDA is a Hidden…

Permits the identification of immunoglobulin rearrangements. SoDA is a Hidden Markov Model (HMM) approach used to compute the posterior probabilities of candidate rearrangements and to find those…

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