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IMonitor | A Pipeline for TCR and BCR Repertoire Analysis

Utilizes re-alignment to identify V(D)J genes and alleles after common local alignment. A methodology is developed to correct the PCR and sequencing errors, and to minimize the PCR bias among various rearranged sequences with different V and J gene families. IMonitor provides general adaptation for sequences from all receptor chains of different species and outputs useful statistics and visualizations. Usefulness of IMonitor was demonstrated on minimal residual disease detection of patients with B-cell Acute Lymphoblastic leukemia.

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IMonitor forum

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IMonitor classification

  • Animals
  • Fungi
  • Plants
  • Protists

IMonitor specifications

Unique identifier:
Command line interface
Input format:
Biological technology:
Programming languages:
C++, Perl, R
Software type:
Restrictions to use:
Output data:
clonotype table, various reports
Operating system:
Computer skills:

IMonitor distribution


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IMonitor support



  • Xiao Liu <>


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BGI-Shenzhen, Shenzhen, China

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