Utilizes re-alignment to identify V(D)J genes and alleles after common local alignment. A methodology is developed to correct the PCR and sequencing errors, and to minimize the PCR bias among various rearranged sequences with different V and J gene families. IMonitor provides general adaptation for sequences from all receptor chains of different species and outputs useful statistics and visualizations. Usefulness of IMonitor was demonstrated on minimal residual disease detection of patients with B-cell Acute Lymphoblastic leukemia.

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IMonitor forum

No open topic.

IMonitor versioning

No versioning.

IMonitor classification

  • Animals
  • Fungi
  • Plants
  • Protists

IMonitor specifications

Software type:
Package
Restrictions to use:
None
Output data:
clonotype table, various reports
Operating system:
Unix/Linux
Computer skills:
Advanced
Interface:
Command line interface
Input data:
fastq/fasta
Biological technology:
Illumina
Programming languages:
C++, Perl, R
Stability:
Stable

IMonitor support

Maintainer

Credits

Publications

  • (Zhang et al., 2015) IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis. Genetics.
    PMID: 26297338

Institution(s)

BGI-Shenzhen, Shenzhen, 518083, China

Link to literature

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